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Hormone therapy can improve mental health and quality of life for people with gender dysphoria, but long-term effects need more research.

The safety and effectiveness of gender-affirming treatments for children are uncertain, with potential long-term risks like infertility.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Most youth with gender dysphoria received hormones, had minor complications, and showed a decrease in suicide attempts after treatment.

The conclusion is that published guidelines are improving transgender medical care, but more research and education in transgender medicine are needed.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

Testosterone therapy is generally safe for transmen, improves sexual function, and has manageable health risks with proper monitoring.

The document advises health care providers on how to support transgender and gender-diverse youth with appropriate care and referrals.

A young Saudi girl with uncontrolled type 1 diabetes and hypothyroidism had two rare conditions, Mauriac syndrome and Van Wyk–Grumbach syndrome.

Precocious puberty can signal familial adenomatous polyposis.

Early diagnosis and treatment with Leuprolide are key for children with precocious puberty.

Treating early puberty with hormone therapy may increase the risk of polycystic ovary syndrome in adults.

An 8-year-old boy's early puberty was caused by a rare hormone-secreting brain tumor, which was successfully treated with surgery.

A 24-month-old Nigerian girl developed early puberty with no family history, needing treatment her family couldn't afford.

Late puberty may slightly lower prostate cancer risk, baldness is not linked to overall risk but less so with aggressive types, ibuprofen use may increase risk, and vitamins show no effect on risk.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

Early puberty is more common in girls and African-American children, possibly due to nutrition, obesity, stress, and environmental factors, and is treated with hormone therapy.

Hormones, especially testosterone and DHT, are key for penis development and function, and testosterone therapy may help with erectile dysfunction in those with low levels.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

A boy with early puberty and laughing seizures was treated, stopping seizures and slowing puberty.

PCOS can cause unusual symptoms like late puberty and enlarged clitoris, making diagnosis difficult.

Metabolic syndrome can cause serious health issues and should be considered when treating women with severe acne.

Ring Chromosome 11 may be linked to conditions like early puberty, excessive hair growth, hair loss, and type 2 diabetes.

Eating high-glycemic and dairy foods can increase hormones that may cause acne and other health issues.

A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.

FPHL common in Taiwanese women; risk factors include BMI, high glucose, early puberty, fewer childbirths, oral contraceptives, and UV exposure.

Early adrenal gland maturation in young children can be normal, but other serious conditions should be ruled out first.

Precocious puberty is starting earlier due to factors like obesity and chemicals, with treatment focusing on preserving height and addressing social issues.

Precocious puberty in girls is linked to cosmetics, pollution, light exposure, early sexual information, diet, and hereditary factors.

A 19-year-old male with delayed puberty was successfully treated for a condition that prevents normal hormone production.