Hypothalamic Hamartoma with Precocious Puberty and Gelastic Seizures in a Boy: Case Report
TLDR A boy with early puberty and laughing seizures was treated, stopping seizures and slowing puberty.
This case report described a 5-year and 7-month-old boy with hypothalamic hamartoma presenting with pubertas precox and gelastic seizures. The boy exhibited premature pubic hair growth, frequent uncontrolled laughing, and accelerated height growth. Laboratory tests showed elevated levels of FSH, LH, testosterone, and 17α-hydroxyprogesterone. Imaging revealed a lesion in the suprasellar region. He was treated with leuprorelin and valproic acid. After 3 years, his pubertal status remained stable, and his bone age was appropriate for a 13-year-old, with no gelastic seizures reported. The report noted that while leuprorelin's effectiveness for pubertas precox in hypothalamic hamartoma is controversial, valproic acid was effective for managing gelastic seizures.
