October 2013 in “International Journal of Pediatric Endocrinology/International journal of pediatric endocrinology” This case report describes a boy with hypothalamic hamartoma experiencing pubertas precox and gelastic seizures, where leuprorelin therapy's effect on pubertas precox was controversial, but valproic acid effectively managed gelastic seizures.
192 citations
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January 1976 in “The Journal of Clinical Endocrinology & Metabolism” This study observed that androgen levels rise with pubic hair development in Tanner stages, differing by sex and age, with DHEA showing a significant prepubertal increase especially in precocious adrenarche.
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July 2015 in “Pediatrics in review” This review discusses factors influencing the earlier onset of puberty, such as obesity and exposure to endocrine-disrupting chemicals, and emphasizes the need for further research and public health policy development.
April 2025 in “International Journal For Multidisciplinary Research” This case report details the investigation and management of a 3-year-old girl with precocious pseudopuberty due to a Sertoli-Leydig cell tumor, highlighting the importance of early recognition and accurate diagnosis for effective treatment and prognosis.
July 2026 in “Frontiers in Endocrinology” This case report describes a 19-month-old girl with androgen-dominant virilization caused by an adrenal tumor, highlighting the importance of adrenal assessment in young girls with such symptoms and recommending long-term monitoring even after initial biochemical remission.