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In this study, novel substituted benzoyl benzoic acids and phenylacetic acids were potent and selective inhibitors of human steroid 5alpha-reductase type 2, with one compound showing promising bioavailability in rats for potential clinical evaluation.

This study found that enzyme activity related to cancer induction by polycyclic aromatic hydrocarbons can be increased by using a shampoo containing crude coal tar and significantly inhibited by imidazole compounds in human hair follicles.

This article proposes a strategy for identifying bioactive, small molecule, metallo-species in Traditional Chinese Medicine to explore their potential for drug development, but reports no new results.

This research discusses various collaborative and funding efforts across multiple institutions but does not present new experimental findings.

This study suggests that PF-0998425 is an effective androgen receptor antagonist for sebum control and androgenetic alopecia with rapid metabolism reducing the risk of systemic side effects.

This study developed the CATNIP computational model, which uses biological and chemical information to successfully identify drug repurposing opportunities for various conditions, including Parkinson’s disease and Type 2 Diabetes.

This study synthesized and evaluated five 6-mercaptopurine derivatives for anticancer activity against three cancer cell lines, detailing the promising results of compound 1.

This paper discusses various toxicological properties of diphenyl cresyl phosphate, highlighting its low acute toxicity, potential neurotoxicity linked to o-cresyl phosphate content, and the lack of data for inhalation exposure, but presents no new experimental findings.

This abstract lists numerous topics and classifications related to drug-induced dermatological conditions and treatments but does not convey new research findings.

This study established a sensitive and reproducible method for determining the levels of four organic solvents in finasteride raw materials, meeting the requirements of the Chinese Pharmacopeia.

This study reports that the dye peri-xanthenoxanthene (PXX) can act as an efficient photocatalyst for various radical reactions, including complex dual catalytic processes and the synthesis of an investigational drug intermediate.

This article discusses the metabolism of benzo(a)pyrene in chemical carcinogenesis and reports no new experimental findings.

This analysis highlighted the importance of integrating scientific literacy into chemical hair procedures, emphasizing that understanding the interaction of chemical agents with hair's biological structure and making evidence-based decisions can improve safety, predictability, and professional standards in the beauty industry.

This chapter reviews various chemical synthesis methods for pharmaceutical compounds and reports no new experimental results.

This review highlights the complex role of scientific knowledge and professional expertise in safely performing chemical hair procedures, emphasizing the importance of education to prevent potential adverse effects like hair damage and scalp irritation.

This study found that several preservatives, including triclocarban and triclosan, showed potential endocrine-disrupting effects on various nuclear receptors in both in silico and in vitro models.

This chapter discusses the synthesis and analysis of near-infrared fluorescent activity-based probes for imaging cysteine protease activity, reporting potential benefits for disease diagnosis but noting challenges in imaging specific locations with high cathepsin activity.

This study reports on a new semantic annotation approach used to identify substances in MEDLINE abstracts responsible for adverse drug reactions, with promising performance shown by a prototype system.

This study describes the molecular conformation and intermolecular interactions in the crystalline structure of the compound C24H31BrO4.

This review highlights the low uptake of tamoxifen and finasteride for cancer chemoprevention in primary care, citing various barriers and indicating a need for safer, more affordable options.

This study developed a high-throughput method that identifies bioactive chemicals influencing DHT production in prostate cancer cells, with potential nutraceutical candidates including fucoxanthin, phenethyl caffeate, and Curcuma longa L. extract.

This synthesis report details the successful development of a C-14 labeled isotopomer of LY300502, a 5α-reductase inhibitor, through a multi-step radiochemical process.

The document shows the state of pharmaceutical patents as of 1999, focusing on treatments for various diseases.

This study suggests that true binary and ternary inclusion complexes were formed between finasteride and 2-hydroxypropyl-ß-cyclodextrin, with or without the addition of specific polymers.

This article discusses the potential for combining PROTACs with other therapeutic modalities in drug discovery and reports no clinical results.