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    Did you mean Protein Kinase C?
    Glossary Protein Kinase C

    enzymes that regulate various cellular functions by phosphorylating proteins

    Protein Kinase C (PKC) is a family of enzymes that play a crucial role in several cellular processes, including cell growth, differentiation, and apoptosis (programmed cell death). These enzymes are activated by signals such as increases in the concentration of calcium ions or diacylglycerol (DAG), and they function by phosphorylating various target proteins, thereby altering their activity. PKC is significant in many physiological and pathological processes, making it a key focus in research related to cancer, cardiovascular diseases, and neurological disorders.

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    1. Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2 Cancer Research · 2006 · 35 citations
    2. Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3 Cancer Research · 2007 · 76 citations
    3. Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶ Photochemistry and Photobiology · 2005 · 28 citations
    4. Protein Kinase C<i>ε</i>, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells Journal of skin cancer · 2013 · 10 citations
    5. Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism<sup>¶</sup> Photochemistry and Photobiology · 2005 · 3 citations
    6. Topical Application of a Protein Kinase C Inhibitor Reduces Skin and Hair Pigmentation 2004 · 60 citations
    7. Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells. Molecular Endocrinology · 1994
    8. Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion. PubMed · 2000 · 99 citations
    9. 2,3,7,8‐Tetrachlorodibenzo‐<i>p</i>‐dioxin causes an increase in protein kinases growth hepatic associated with epidermal factor receptor in the plasma membrane Journal of Biochemical Toxicology · 1988 · 60 citations
    10. Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. PubMed · 2003 · 26 citations
    11. Atypical Protein Kinase C Isoform, aPKCλ, Is Essential for Maintaining Hair Follicle Stem Cell Quiescence Journal of Investigative Dermatology · 2015 · 24 citations
    12. Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. PubMed · 2003 · 79 citations
    13. Melatonin regulates the mitogen-activated protein kinase ( MAPK ) pathway via the circMPP5-miR-211-MAPK3 axis to induce secondary hair follicle differentiation and development in newborn Cashmere goat kids Research Square (Research Square) · 2022 · 1 citations
    14. A Ca <sup>2+</sup> /calmodulin-dependent protein kinase required for symbiotic nodule development: Gene identification by transcript-based cloning Proceedings of the National Academy of Sciences · 2004 · 477 citations
    15. Several Selective Protein Kinase C Inhibitors Including Procyanidins Promote Hair Growth Skin pharmacology and physiology · 2000 · 32 citations
    16. Bioinformatic analysis of gene expression data reveals Src family protein tyrosine kinases as key players in androgenetic alopecia Frontiers in Medicine · 2023
    17. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    18. 078 The transmembrane protein LRIG1 regulates receptor tyrosine kinases in skin development and homeostasis Journal of Investigative Dermatology · 2017
    19. Phosphatidic Acid Has a Potential to Promote Hair Growth In Vitro and In Vivo, and Activates Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase in Hair Epithelial Cells 2003 · 46 citations
    20. Salicylate induces epithelial actin reorganization via activation of the AMP-activated protein kinase and promotes wound healing and contraction in mice Scientific Reports · 2024 · 8 citations
    21. AMP-activated Protein Kinase 활성체인 Metformin의 모발 성장에 미치는 영향 대한피부과학회지 · 2019
    22. The G-Protein Couple Receptor Kinase 2 (GRK2) Orchestrates Hair Follicle Homeostasis bioRxiv (Cold Spring Harbor Laboratory) · 2024
    23. Type I Keratin 17 Protein Is Phosphorylated on Serine 44 by p90 Ribosomal Protein S6 Kinase 1 (RSK1) in a Growth- and Stress-dependent Fashion 2011 · 30 citations
    24. Androgens Induce Nongenomic Stimulation of Colonic Contractile Activity through Induction of Calcium Sensitization and Phosphorylation of LC20 and CPI-17 Molecular Endocrinology · 2010 · 31 citations
    25. Wedelolactone, a medicinal plant-derived coumestan, induces caspase-dependent apoptosis in prostate cancer cells via downregulation of PKCε without inhibiting Akt International Journal of Oncology · 2012 · 83 citations
    26. Protein Kinase C as a Therapeutic Target Clinical Cancer Research · 2006 · 87 citations
    27. Enzymatic phosphorylation of hair keratin enhances fast adsorption of cationic moieties International Journal of Biological Macromolecules · 2016 · 11 citations
    28. Skin Cancer: Mechanisms and Human Relevance Medical Entomology and Zoology · 1994 · 213 citations
    29. <i>In Vitro</i> and <i>In Vivo</i> Models for the Development of Hair Growth Materials By Regulating the <i>β</i>-Catenin Signaling Pathways Journal of medicinal food · 2024
    30. Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport Journal of ethnopharmacology · 2023