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    Did you mean Protein Kinase C?
    Glossary Protein Kinase C

    enzymes that regulate various cellular functions by phosphorylating proteins

    Protein Kinase C (PKC) is a family of enzymes that play a crucial role in several cellular processes, including cell growth, differentiation, and apoptosis (programmed cell death). These enzymes are activated by signals such as increases in the concentration of calcium ions or diacylglycerol (DAG), and they function by phosphorylating various target proteins, thereby altering their activity. PKC is significant in many physiological and pathological processes, making it a key focus in research related to cancer, cardiovascular diseases, and neurological disorders.

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    1. Inhibition of the development of metastatic squamous cell carcinoma in protein kinase C epsilon transgenic mice by alpha-difluoromethylornithine accompanied by marked hair follicle degeneration and hair loss. PubMed · 2003 · 26 citations
    2. Overexpression of protein kinase C-α in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-α expression but not tumor promotion Journal of Cell Science · 1999 · 135 citations
    3. Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶ Photochemistry and Photobiology · 2005 · 28 citations
    4. Induction of hair growth by skin irritants and its relation to skin protein kinase C isoforms 1999 · 10 citations
    5. Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism<sup>¶</sup> Photochemistry and Photobiology · 2005 · 3 citations
    6. Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids Molecular and Cellular Neuroscience · 2016 · 11 citations
    7. 측백엽(側柏葉) 추출물의 발모효과(發毛效果)에 관한 실험적 연구 동의생리병리학회지 = Journal of physiology & pathology in Korean Medicine · 2007
    8. Androgen-induced norepinephrine release in male accessory sex organ smooth muscle growth and differentiation 2019
    9. Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice. PubMed · 2003 · 79 citations
    10. Cyclosporin A Promotes Hair Epithelial Cell Proliferation and Modulates Protein Kinase C Expression and Translocation in Hair Epithelial Cells Journal of Investigative Dermatology · 2001 · 45 citations
    11. Protein Kinase C<i>ε</i>, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells Journal of skin cancer · 2013 · 10 citations
    12. The Molecular Mechanism Underlying the Proliferating and Preconditioning Effect of Vitamin C on Adipose-Derived Stem Cells Stem Cells and Development · 2014 · 42 citations
    13. Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study 2002 · 37 citations
    14. Comparative analysis of stemness between dermal papilla cells and human dermalstem/progenitor cells Cellular and Molecular Biology · 2025
    15. Differences in cell subsets between sun-exposed and unexposed skin: preliminary single-cell sequencing and biological analysis from a single case Frontiers in Medicine · 2024 · 3 citations
    16. Claudin Expression Modulations Reflect an Injury Response in the Murine Epidermis Journal of Investigative Dermatology · 2007 · 9 citations
    17. Regulation of Involucrin Gene Expression Journal of Investigative Dermatology · 2004 · 138 citations
    18. PKC downregulation upon rapamycin treatment attenuates mitochondrial disease Nature metabolism · 2020 · 26 citations
    19. Type XVII collagen coordinates proliferation in the interfollicular epidermis eLife · 2017 · 124 citations
    20. Wnt/β-Catenin Signaling Stabilizes Hemidesmosomes in Keratinocytes 2021 · 5 citations
    21. A novel immune competent murine hypertrophic scar contracture model: A tool to elucidate disease mechanism and develop new therapies Wound Repair and Regeneration · 2014 · 35 citations
    22. Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARα and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways Journal of Cellular Biochemistry · 2005 · 24 citations
    23. Lipid signaling in keratinocytes: Lipin-1 plays a PArt Journal of lipid research · 2016 · 1 citations
    24. Genetic alteration of cyclic adenosine 3',5'-monophosphate-dependent protein kinase subunit expression affects calcium currents and beta-endorphin release in AtT-20 clonal pituitary cells. Molecular Endocrinology · 1994
    25. Protein kinase Akt2/PKBβ is involved in blastomere proliferation of preimplantation mouse embryos Journal of Cellular Physiology · 2019 · 7 citations
    26. C‐reactive protein promotes adhesion of monocytes to endothelial cells via NADPH oxidase‐mediated oxidative stress Journal of Cellular Biochemistry · 2012 · 24 citations
    27. Purified Vitexin Compound 1 Inhibits UVA-Induced Cellular Senescence in Human Dermal Fibroblasts by Binding Mitogen-Activated Protein Kinase 1 Frontiers in Cell and Developmental Biology · 2020 · 3 citations
    28. Expression and Distribution of the Guanine Nucleotide-binding Protein Subunit Alpha-s in Mice Skin Tissues and Its Association with White and Black Coat Colors Asian-Australasian journal of animal sciences · 2016 · 1 citations
    29. <i>Malva verticillata</i>seed extracts upregulate the Wnt pathway in human dermal papilla cells International Journal of Cosmetic Science · 2015 · 25 citations
    30. Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review Archives of Dermatological Research · 2025 · 3 citations