Search
for

    Glossary Proteases

    Proteases are enzymes that catalyze the breakdown of proteins into smaller peptides or amino acids by cleaving peptide bonds. In the context of hair loss and hair biology, proteases play a crucial role in various physiological processes, including hair follicle cycling and the regulation of hair growth. Dysregulation of protease activity can contribute to conditions such as androgenetic alopecia, where excessive proteolytic activity may lead to follicle miniaturization and hair thinning. Key distinguishing characteristics of proteases include their specificity for different peptide bonds and their classification into various families based on their catalytic mechanisms, such as serine, cysteine, and metalloproteases.

    Related Terms

    Sort by

    Research 30 of 1000+

    1. Epidermal differentiation: The role of proteases and their inhibitors European Journal of Cell Biology · 2004 · 118 citations
    2. The mRNA for Protease Nexin-1 is Expressed in Human Dermal Papilla Cells and its Level is Affected by Androgen Journal of Investigative Dermatology · 1999 · 27 citations
    3. Nagashima-Type Palmoplantar Keratosis: A Common Asian Type Caused by SERPINB7 Protease Inhibitor Deficiency Journal of Investigative Dermatology · 2014 · 24 citations
    4. Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract Pharmacology Research & Perspectives · 2020 · 15 citations
    5. The CAP1/Prss8 catalytic triad is not involved in PAR2 activation and protease nexin‐1 (PN‐1) inhibition The FASEB Journal · 2014 · 14 citations
    6. Protease activity, localization and inhibition in the human hair follicle International Journal of Cosmetic Science · 2013 · 11 citations
    7. Protease-Activated Receptor-1 (Thrombin Receptor) Is Expressed in Mesenchymal Portions of Human Hair Follicle Journal of Investigative Dermatology · 2003 · 7 citations
    8. Properties of Partially Extracted Hairs and their Degradability by Proteases Sen'i Gakkaishi · 2007
    9. An Integrated Two-Step Enzymatic Unhairing Strategy: Eliminating the Penetration Barrier via Soaking To Enhance Targeted Protease Action Industrial & Engineering Chemistry Research · 2026
    10. The mouse frizzy (<i>fr</i>) and rat ‘hairless’ (<i>fr</i><sup><i>CR</i></sup>) mutations are natural variants of protease serine S1 family member 8 (<i>Prss8</i>) Experimental Dermatology · 2010 · 28 citations
    11. Polygenic control of the wavy coat of the NCT mouse: involvement of an intracisternal A particle insertional mutation of the protease, serine 53 (Prss53) gene, and a modifier gene Mammalian Genome · 2022
    12. Message of protease nexin-1 is expressed in human dermal papilla cells and is affected by androgen Journal of dermatological science · 1998
    13. Message of nexin 1, a serine protease inhibitor, is accumulated in the follicular papilla during anagen of the hair cycle Journal of Cell Science · 1995 · 37 citations
    14. Keratinocyte-Specific Onset of Serine Protease BSSP Expression in Experimental Carcinogenesis Journal of Investigative Dermatology · 2001 · 26 citations
    15. Colocalization of Cystatin M/E and its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail 2008 · 22 citations
    16. Bikunin, a Serine Protease Inhibitor, is Present on the Cell Boundary of Epidermis Journal of Investigative Dermatology · 1999 · 13 citations
    17. Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403. PubMed · 2001 · 1 citations
    18. Cell Type-specific Functions of the Lysosomal Protease Cathepsin L in the Heart Journal of Biological Chemistry · 2007 · 56 citations
    19. Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity 2019 · 39 citations
    20. A Novel Serine Protease Overexpressed in the Hair Follicles of Nude Mice Biochemical and Biophysical Research Communications · 1999 · 32 citations
    21. Regulatory Processes of the Canonical Wnt/β-Catenin Pathway and Photobiomodulation in Diabetic Wound Repair International Journal of Molecular Sciences · 2022 · 11 citations
    22. The protease corin regulates electrolyte homeostasis in eccrine sweat glands PLoS biology · 2021 · 10 citations
    23. Male balding as a major risk factor for severe COVID-19: A possible role for targeting androgens and transmembrane protease serine 2 to protect vulnerable individuals Journal of The American Academy of Dermatology · 2020 · 6 citations
    24. Rand Protease: The Role of Calcium-Binding Site on Stability with Mutagenesis and The Effectiveness on Leather Dehairing Sains Malaysiana · 2023
    25. Ageing processes influence keratin and KAP expression in human hair follicles Experimental Dermatology · 2011 · 35 citations
    26. Synaptic processes and immune-related pathways implicated in Tourette syndrome Translational Psychiatry · 2021 · 29 citations
    27. Synaptic processes and immune-related pathways implicated in Tourette Syndrome medRxiv (Cold Spring Harbor Laboratory) · 2020 · 1 citations
    28. Mitotic processes in hair follicles and the morphostructure of sheep skin upon inclusion of a water-soluble fatty acid complex into their diets Ukrainian Journal of Veterinary and Agricultural Sciences · 2025
    29. Assessment of Dysregulation of HERC6 and Essential Biological Processes in Response to Laser Therapy of Human Arm Skin Journal of lasers in medical sciences · 2020
    30. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002 · 146 citations