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The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Finasteride and minoxidil are effective for hair regrowth, while treatments for alopecia areata have varying success and continuous treatment is necessary.

Stress increases a factor in mice that leads to hair loss, and blocking this factor may prevent it.

Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.

Use "female pattern hair loss" term, assess androgen excess, treat with minoxidil and other medications if needed.

Cytokines and neuropeptides are key in controlling androgen levels, affecting skin and hair conditions.

Blocking JAK/STAT pathways can help treat hair loss from alopecia areata.

Signaling pathways are crucial for hair growth in goats.

Lower lipin 1β in belly fat is linked to insulin resistance in people with polycystic ovary syndrome.

Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.

COVID-19 may harm male fertility and damage the reproductive system.

A specific microRNA, chi-miR-30b-5p, slows down the growth of hair-related cells by affecting the CaMKIIδ gene in cashmere goats.

Chromium supplements don't help with weight loss or improve hormone and metabolism issues in people with polycystic ovary syndrome.

COVID-19 may affect male fertility and women might have better outcomes due to hormonal and immune differences.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

A specific RNA molecule, circCOL1A1, affects the growth and quality of goat hair by interacting with miR-149-5p and influencing cell growth pathways.

The PLP2 gene affects cashmere fiber quality in goats and is linked to hair growth and loss.

Early-onset baldness is linked to genetics, lifestyle, and can indicate higher risk for heart and metabolic diseases, and affects mental health.

The gene Foxn1 is important for hair growth, and understanding it may lead to new alopecia treatments.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Androgens can both increase and decrease hair growth in different parts of the body.

Androgens can cause hair growth in some areas and hair loss on the scalp.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

MicroRNA-214 is important for skin and hair growth because it affects the Wnt pathway.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Minoxidil and finasteride effectively treat hair loss.

Menopause reduces skin collagen and elasticity, and while estrogen therapy can help, its risks require careful consideration.

The document concludes that accurate measurement of serum androgens is crucial for diagnosing hyperandrogenism.