10 citations
,
October 2017 in “Pediatric neurology” This case report suggests that poor hair and nail growth in children with autism spectrum disorder and developmental delay may indicate a biotin-responsive condition, as biotin and acetazolamide therapy improved symptoms and school performance in the reported patient.
5 citations
,
February 2003 in “American Journal of Medical Genetics Part A” This case report describes a 6.5-year-old girl with a balanced chromosome translocation involving chromosomes 1 and 6, linked to developmental speech delay and features suggestive of ectodermal dysplasia.
February 2010 in “Journal of The American Academy of Dermatology” A woman's nail separation was likely caused by poor blood flow, and a treatment for similar conditions might help.
March 2025 in “Dermatology” Systemic therapies improve nail psoriasis but have high side effects; more research is needed.
2 citations
,
December 2015 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study reports that targeted anticancer therapies frequently cause skin-related side effects, which may impact patient adherence and quality of life, but these effects are positively correlated with treatment response.
March 2014 in “Journal of The American Academy of Dermatology” Terbinafine 250 mg is the most effective treatment for fungal nail infections.
June 2021 in “Dermatology Online Journal” This case report documents the first known occurrence of alopecia areata in a patient with ectodermal dysplasia linked to a WNT10A mutation, suggesting potential shared genetic factors in hair loss pathways.
11 citations
,
January 2014 in “The Scientific World Journal” This study found that Cynatine HNS significantly improved hair and nail health in women after 90 days compared to placebo.
1 citations
,
February 2022 in “Biological Trace Element Research” In this animal study, applying a combination of inositol-stabilized arginine silicate complex and magnesium biotinate promoted hair growth but not nail growth.
68 citations
,
January 2014 in “Dermatology research and practice” This review discusses the presentation and management of skin toxicity from epidermal growth factor inhibitors, highlighting a correlation between cutaneous adverse effects and tumor response, but reports no new clinical results.
78 citations
,
January 2017 in “Skin appendage disorders” This review discusses the use of biotin for hair and nail growth, noting clinical improvement in cases with existing pathologies, but concludes there is insufficient evidence supporting its benefits for healthy individuals.
2 citations
,
October 2016 This article discusses the range of skin-related side effects caused by chemotherapy and radiotherapy, including novel patterns emerging with targeted therapies, but does not report new clinical results.
139 citations
,
October 2005 in “Journal of Investigative Dermatology” This study describes previously unknown immune characteristics of the normal human nail, highlighting its similarities to the hair follicle immune system and suggesting an immune privilege in the proximal nail matrix that both provides autoimmunity protection and presents infection susceptibility.
42 citations
,
April 2012 in “Seminars in Oncology” This review discusses the skin side effects associated with targeted cancer therapies and reports no new clinical results; it emphasizes the need for empirical management based on expert opinion.
13 citations
,
August 1982 in “Archives of dermatology” This case report describes a 62-year-old man with psoriasis who developed a unique nail abnormality after two months of treatment with the oral retinoid etretinate, alongside hair thinning and cheilitis.
22 citations
,
March 2017 in “Journal of the Formosan Medical Association” This report presents the Taiwanese Dermatological Association's 2016 consensus on defining and managing skin toxicities from EGFR-TKI treatments, providing comprehensive guidelines for clinicians in Taiwan.
January 2022 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)” This article presents an overview of uncombable hair syndrome, emphasizing its clinical and molecular characteristics and noting systemic manifestations such as neuropsychiatric, ophthalmic, and cardiopulmonary issues.
July 2025 in “Cosmoderma” In this study, a 90-day course of a plant-based supplement significantly improved hair density, skin hydration, and nail growth among participants with dermatological concerns, while also reducing hair fall and pigmentation, without adverse effects.
1 citations
,
June 2023 in “Medicina” In this study, all 26 patients with epidermolysis bullosa were found to have extensive dental caries, with various dental and oral complications varying by EB type, due in part to inadequate oral care and associated physical limitations.
July 1980 in “Journal of The American Academy of Dermatology” The conference concluded that understanding hair and nail disorders is important, iron deficiency may be linked to hair loss, and while some treatments for skin conditions are effective, they may have risks and high costs.
32 citations
,
January 2012 in “International Journal of Dermatology” This study reported that the most common skin side effect of epidermal growth factor receptor inhibitors was a papulopustular rash, treatable with symptom-targeted therapies, while drug suspension was rarely needed.
September 1997 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” The document concludes that treatments like oral anti-androgens, minoxidil, and topical spironolactone can be effective for hair loss in men and women.
January 2014 in “Pathology” The document concludes that understanding nail anatomy is key for diagnosing nail diseases, early signs of nail melanoma may allow for less aggressive treatment, and specific genetic mutations are important in thyroid cancer prognosis and treatment.
4 citations
,
August 2018 in “Journal of The American Academy of Dermatology” This response article concurs with Dr. Lipner's critique that biotin supplementation is largely unsupported for routine use in dermatological conditions, with evidence mostly limited to case reports.
1 citations
,
December 2024 in “Cosmoderma” This study reported that Nyumi Happy Hair Gummies improved hair growth, thickness, density, and gloss in adults with hair fall, while also reducing hair fall and enhancing nail health, without any adverse effects reported during the trial.
202 citations
,
August 2007 in “Biomaterials” This review discusses advancements in artificial skin for wound treatment and reports no new clinical findings; the authors highlight the potential of new biomaterials to enhance future skin replacement therapies.
September 1997 in “Journal of The European Academy of Dermatology and Venereology” Topical spironolactone effectively treats hair loss in women.
96 citations
,
January 1997 in “Clinics in Dermatology” This study found that G protein-coupled estrogen receptor enhances melanin synthesis in melanoma cells through cAMP-PKA-MITF-TYR signaling, suggesting its potential as a drug target for chloasma treatment.
6 citations
,
April 2024 in “Health Science Reports” This study found that young patients with severe AA are more prone to nail abnormalities such as pitting and leukonychia, with koilonychia and red spots lunula in more severe cases.
September 2017 in “Pediatric Dermatology” No results are reported in this correspondence published in Pediatric Dermatology, as it responds to prior communication about contact dermatitis related to alopecia and hyperpigmentation.