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    Did you mean Phosphodiesterase Inhibitors?
    Glossary Phosphodiesterase Inhibitors

    block enzymes that break down cyclic nucleotides

    Phosphodiesterase Inhibitors (PDE Inhibitors or PDEIs) are a class of drugs that block the action of phosphodiesterase enzymes, which are responsible for breaking down cyclic nucleotides like cAMP and cGMP. By inhibiting these enzymes, PDE inhibitors can increase the levels of these cyclic nucleotides, leading to various therapeutic effects such as vasodilation, anti-inflammatory actions, and improved cardiac function. These drugs are used to treat conditions like erectile dysfunction, pulmonary hypertension, and certain types of heart failure.

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    Research 30 of 513

    1. Therapeutic use of caffeine in dermatology: A literature review Journal of Dermatology and Dermatologic Surgery · 2020 · 5 citations
    2. 570 Targeting phosphodiesterase 8A (PDE8A) to boost adipogenesis and hair regeneration Journal of Investigative Dermatology · 2024
    3. Tribuloside acts on the PDE/cAMP/PKA pathway to enhance melanogenesis, melanocyte dendricity and melanosome transport Journal of ethnopharmacology · 2023
    4. Role of caffeine in the management of androgenetic alopecia International Journal of Trichology · 2012 · 11 citations
    5. INTERACTION OF α-MELANOCYTE-STIMULATING HORMONE, MELATONIN, CYCLIC AMP AND CYCLIC GMP IN THE CONTROL OF MELANOGENESIS IN HAIR FOLLICLE MELANOCYTES IN VITRO Journal of Endocrinology · 1981 · 53 citations
    6. Caffeine’s Mechanisms of Action and Its Cosmetic Use Skin Pharmacology and Physiology · 2012 · 153 citations
    7. Caffeine and Its Role in Regulation the Androgenetic Alopecia. 2021
    8. Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis Journal of Advanced Research · 2024 · 8 citations
    9. Most recent findings of curative drugs for lower urinary tract symptoms in clinical practice Nihon Yakuri Gakkai nenkai yoshishu · 2019
    10. A COMPREHENSIVE REVIEW ON PHARMACOLOGICAL POTENTIALS OF CAFFEINE Journal of Applied Pharmaceutical Sciences and Research · 2023 · 12 citations
    11. Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review Dermatologic Therapy · 2020 · 9 citations
    12. Inhibition of SARS-CoV-2 entry through the ACE2/TMPRSS2 pathway: a promising approach for uncovering early COVID-19 drug therapies European Journal of Clinical Pharmacology · 2020 · 77 citations
    13. Inhibition of Insulin-Like Growth Factor-1–Induced Sebum Production by Bilobetin in Cultured Human Sebocytes Annals of Dermatology · 2019 · 8 citations
    14. Trends in the Development of New Drugs for Treatment of Benign Prostatic Hyperplasia Current Medicinal Chemistry · 2006 · 14 citations
    15. Adverse effects of common medications on male fertility Nature Reviews Urology · 2015 · 77 citations
    16. Pharmacological Approaches in Managing Symptomatic Relief of Benign Prostatic Hyperplasia: A Comprehensive Review Curēus · 2023 · 1 citations
    17. Efficacy and Side Effects of Drugs Commonly Used for the Treatment of Lower Urinary Tract Symptoms Associated With Benign Prostatic Hyperplasia Frontiers in Pharmacology · 2020 · 35 citations
    18. 5-Alpha-Reductase Inhibitors and Combination Therapy Urologic Clinics of North America · 2016 · 15 citations
    19. Sexual Dysfunction Related to Drugs: a Critical Review. Part V: α-Blocker and 5-ARI Drugs Pharmacopsychiatry · 2015 · 15 citations
    20. Alopesi Tedavisinde Kullanılan İlaç Tedavileri ve Yeni Yaklaşımlar 2025
    21. 467 Novel selective phosphodiesterase inhibitors promote the adipogenic function of dermal fibroblasts: Implication to treat hair loss Journal of Investigative Dermatology · 2021
    22. Phosphodiesterase (PDE) Inhibitors for the Treatment of Inflammatory Skin Conditions Springer eBooks · 2018
    23. Lipid Profile and 5α-Reductase Inhibition Activity of Proprietary Ultrahigh-Pressure Supercritical Carbon Dioxide and Hexane Saw Palmetto Extracts Uro · 2023 · 2 citations
    24. IN SILICO STUDY OF 12 PHYTOSTEROL COMPOUNDS IN MORINGA (MORINGA OLEIFERA LAMK.) SEED OIL ON 5Α-REDUCTASE ENZYME INHIBITION ACTIVITY AS ANTI-ALOPECIA International Journal of Applied Pharmaceutics · 2022
    25. Evaluating the safety profile of α-1 blockers, 5α-reductase inhibitors, and PDE5I for BPH: a disproportionality analysis of real-world adverse events based on FDA adverse event reporting system (FAERS) The Aging Male · 2026
    26. Anti‐hair loss effect of a shampoo containing caffeine and adenosine Journal of cosmetic dermatology · 2024
    27. Cytokine Targeted Therapeutics for Alopecia Areata: Lessons from Atopic Dermatitis and Other Inflammatory Skin Diseases 2017 · 25 citations
    28. Monovalent antibody-conjugated lipid-polymer nanohybrids for active targeting to desmoglein 3 of keratinocytes to attenuate psoriasiform inflammation Theranostics · 2021 · 18 citations
    29. Risks and side effects in the medical management of benign prostatic hyperplasia Prostate International · 2023 · 26 citations
    30. Enhanced remyelination during late pregnancy: involvement of the GABAergic system Scientific Reports · 2019 · 30 citations