Search
for

    Did you mean Phosphodiesterase?
    Glossary Phosphodiesterase

    enzyme that breaks down cyclic nucleotides in cells

    Phosphodiesterase (PDE) is an enzyme that plays a crucial role in cellular signaling by breaking down cyclic nucleotides like cAMP and cGMP, which are molecules that transmit signals inside cells. By regulating the levels of these cyclic nucleotides, PDEs help control various physiological processes, including heart rate, inflammation, and even hair growth.

    Related Terms

    Sort by

    Research 30 of 552

    1. Effect of a transcriptional inactive or absent vitamin D receptor on beta-cell function and glucose homeostasis in mice 2016 · 13 citations
    2. White Lupin Cluster Root Acclimation to Phosphorus Deficiency and Root Hair Development Involve Unique Glycerophosphodiester Phosphodiesterases Plant physiology · 2011 · 80 citations
    3. Insights learned from L457(3.43)R, an activating mutant of the human lutropin receptor Molecular and Cellular Endocrinology · 2006 · 17 citations
    4. 5-Alpha-Reductase Inhibitors and Combination Therapy Urologic Clinics of North America · 2016 · 15 citations
    5. Trends in the Development of New Drugs for Treatment of Benign Prostatic Hyperplasia Current Medicinal Chemistry · 2006 · 14 citations
    6. Finasteride, not tamsulosin, increases severity of erectile dysfunction and decreases testosterone levels in men with benign prostatic hyperplasia Hormone Molecular Biology and Clinical Investigation · 2015 · 20 citations
    7. Chronic graft-versus-host disease – the role of dermatological treatment Dermatology Review · 2017
    8. Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6 Proceedings of the National Academy of Sciences · 2025 · 1 citations
    9. Risk of erectile dysfunction associated with use of 5-α reductase inhibitors for benign prostatic hyperplasia or alopecia: population based studies using the Clinical Practice Research Datalink BMJ · 2016 · 30 citations
    10. What do we know about phytotherapy of benign prostatic hyperplasia? Life Sciences · 2015 · 67 citations
    11. Recent Advances in Drug Design and Drug Discovery for Androgen- Dependent Diseases Current Medicinal Chemistry · 2016 · 11 citations
    12. Deletion of adipocyte Sine Oculis Homeobox Homolog 1 prevents lipolysis and attenuates skin fibrosis 2024
    13. A review of the treatment of male pattern hair loss Expert Opinion on Pharmacotherapy · 2020 · 53 citations
    14. Transepidermal UV radiation of scalp skin <i>ex vivo</i> induces hair follicle damage that is alleviated by the topical treatment with caffeine International Journal of Cosmetic Science · 2019 · 31 citations
    15. Repositioning Old Drugs for New Battles: The Expanding Role of Drug Repurposing in Cancer, Inflammation, and Metabolic Disease. BIOMED natural and applied science · 2025 · 3 citations
    16. Differentiation of Adipose Derived Stem Cells by Stimulating with Extracellular Vesicles Secreted from Dermal Papilla Cells Activated with Osteogenic and Adipogenic Inducers Institutional Repositories DataBase (IRDB) · 2022
    17. Alopecia Areata: An Updated Review for 2023 Journal of Cutaneous Medicine and Surgery · 2023 · 91 citations
    18. New effects of caffeine on corticotropin‐releasing hormone (CRH)‐induced stress along the intrafollicular classical hypothalamic–pituitary–adrenal (HPA) axis (CRH‐R1/2, IP<sub>3</sub>‐R, ACTH, MC‐R2) and the neurogenic non‐HPA axis (substance P, p75<sup>NTR</sup>and TrkA) in<i>ex vivo</i>human male androgenetic scalp hair follicles British Journal of Dermatology · 2020 · 12 citations
    19. Exploring the mechanism of Platycladi Cacumen in intervening androgenetic alopecia based on network pharmacology, molecular docking, and molecular dynamics simulation Scientific Reports · 2026
    20. Novel Synthetic Steroid Derivatives: Target Prediction and Biological Evaluation of Antiandrogenic Activity Current Issues in Molecular Biology · 2025
    21. Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves Proceedings of the National Academy of Sciences · 2005 · 319 citations
    22. Administration of Nrf-2-Modified Hair-Follicle MSCs Ameliorates DSS-Induced Ulcerative Colitis in Rats Oxidative Medicine and Cellular Longevity · 2021 · 3 citations
    23. Canagliflozin alleviates progestin resistance by suppressing RARβ/CRABP2 signaling in THRB knockout endometrial cancer cells Frontiers in Pharmacology · 2025
    24. In vitro hair growth-promoting effects of araliadiol via the p38/PPAR-γ signaling pathway in human hair follicle stem cells and dermal papilla cells Frontiers in Pharmacology · 2024
    25. The effect of cilostazol, a phosphodiesterase 3 (PDE3) inhibitor, on human hair growth with the dual promoting mechanisms Journal of Dermatological Science · 2018 · 21 citations
    26. Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors 2022 · 12 citations
    27. Efficacy of the phosphodiesterase-4 inhibitor, apremilast, in a patient with severe alopecia areata European Journal of Dermatology · 2019 · 10 citations
    28. Phosphodiesterase inhibitors and prostaglandin analogues in dermatology: A comprehensive review Dermatologic Therapy · 2020 · 9 citations
    29. The use of phosphodiesterase inhibitors for the treatment of alopecia Journal of Dermatological Treatment · 2019 · 3 citations
    30. Comment on ‘Androgenetic alopecia is associated with increased scalp hardness’: role of phosphodiesterase inhibitors? Journal of The European Academy of Dermatology and Venereology · 2020 · 1 citations