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Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

Dextran sulfate was found to be toxic and ineffective for treating HIV.

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.

The niche environment controls stem cell behavior and plasticity, which is important for tissue health and repair.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

Matriptase is crucial for keeping epithelial tissues healthy and functioning properly.

The HR protein helps hair grow by blocking a hair growth inhibitor, aiding in hair follicle regeneration.

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

Exosomes could potentially enhance tissue repair and regeneration with lower rejection risk and easier production than live cell therapies.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

Some vitamins and minerals like vitamin D and iron can help with certain types of hair loss, but more research is needed for others.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

Tempol is safe and may prevent hair loss from brain radiotherapy.

Macrophages help heal nerves by aiding the maturation of Schwann cells and are important for nerve repair.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Gene therapy with the Math1 gene helped regenerate balance-related cells and improve balance in mice.

Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

Stress can cause hair loss by negatively affecting hair follicles and this effect might be reversed with specific treatments.

MicroRNA-302 helps improve the conversion of body cells into stem cells by blocking NR2F2.

Different PIN proteins affect plant root hair growth by changing how auxin is transported.

Hair follicles produce and respond to melatonin, affecting hair growth and sensitivity to estrogen.

Terbinafine quickly builds up in skin and hair, staying effective for over 3 weeks.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Asia has made significant progress in tissue engineering and regenerative medicine, but wider clinical use requires more development.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.