June 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study found a specific T cell receptor that may be key in carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis, suggesting potential therapeutic targets.
March 2011 in “Journal of clinical and experimental investigations” This study describes two thallium poisoning outbreaks, highlighting characteristic symptoms like hair loss and peripheral neuropathy, and emphasizes that such poisoning can stem from accidental or criminal ingestion.
1 citations
,
May 2007 in “Emergency medicine news” This article discusses thallium poisoning and its diagnosis, symptoms, and treatment options, emphasizing the need for awareness due to its misleading symptoms and potential for misdiagnosis.
2 citations
,
January 1999 in “Dermatology”
2 citations
,
June 2011 in “Journal of clinical and experimental investigations” This study found that oral zinc sulphate appeared effective and safe for treating thallium poisoning, particularly in reducing hair and skin symptoms and mitigating its severe progression in patients.
21 citations
,
February 1988 in “Toxicology” This study found that high doses of TCB caused severe toxicity in cotton top marmoset monkeys, with clinical and histological changes similar to those in humans and other primates exposed to PCBs.
88 citations
,
August 2019 in “Nature communications” In this study, researchers identified a specific T cell receptor associated with carbamazepine-induced severe cutaneous adverse reactions, demonstrating its potential for therapeutic development in patients with the HLA-B*15:02 genotype.
52 citations
,
May 2009 in “Human & experimental toxicology” This study reported that despite treatment, patients with severe thallium poisoning experienced lasting visual impairment and partial recovery of polyneuropathy over two years, with hair loss fully reversing.
12 citations
,
August 2014 in “Elsevier eBooks” This article discusses thallium absorption, excretion, and its toxic effects on humans and animals, emphasizing the need for monitoring in areas with significant environmental contamination; no new clinical results are reported.
1 citations
,
October 1935 in “Nature” Potassium iodide prevents hair loss and reduces toxicity from thallium acetate.
6 citations
,
September 2015 in “Journal of Medicinal Chemistry” This study synthesized and verified the structures of Setipiprant's major and minor metabolites, confirming their regio- and enantioselectivity from earlier proposals in a clinical study.
44 citations
,
March 1947 in “Endocrinology” This article reviews hair growth patterns in humans and laboratory animals, noting the random distribution of active and inactive hair follicles and differences in regional coordination among animal species, and reports no new results.
January 1982 in “Clin-Alert” Some medications caused temporary health issues that improved after stopping the drugs, but two patients died from liver problems linked to carbamazepine.
3 citations
,
May 1963 in “Radiology” This article reports on five cases of thallium poisoning seen at Hospital Dos de Mayo, Lima, Peru, highlighting the clinical symptoms and diagnostic features observed, including a case confirmed through various laboratory tests.
June 2011 in “Journal of clinical and experimental investigations” This study suggests that oral zinc sulphate may be an effective and safe treatment for thallium poisoning, particularly in improving dermatological symptoms and reducing the progression of the condition.
April 2007 in “Nature Clinical Practice Urology” TICE salvage chemotherapy is effective for treating germ-cell tumors with poor prognosis.
6 citations
,
January 2012 in “Annals of Indian Academy of Neurology” This study found that women with epilepsy on carbamazepine and sodium valproate monotherapy experienced more significant weight gain but showed no difference in PCOS incidence compared to phenytoin users; elevated TSH levels were more common among those on sodium valproate.
13 citations
,
October 2017 in “Bioorganic & Medicinal Chemistry” This study found that compound 3, a tetrahydropyridoindole carboxymethylated at position 5, significantly inhibited sorbitol accumulation in both rat eye lenses and tissues affected by diabetes, indicating its potential as a lead compound for ALR2 inhibition.
35 citations
,
February 2012 in “The New England Journal of Medicine” Early diagnosis and treatment of TPP can prevent complications.
March 2019 in “Reactions Weekly” 1 citations
,
April 2022 in “The Journal of Urology” This study observed that discontinuation rates due to side effects were similar for penicillamine and tiopronin among cystinuria patients, and switching to the alternative agent was beneficial for half of those experiencing issues.
July 1989 in “British Journal of Dermatology” Long-term use of canthaxanthin may cause reversible changes in the eye, including crystal deposits and altered vision responses.
48 citations
,
January 2008 in “European Neurology” This study demonstrated that acute thallium poisoning primarily manifests with gastrointestinal issues, polyneuropathy, and dermatological changes, and treatments like hemoperfusion and hemodialysis may improve symptoms.
13 citations
,
September 1989 in “International Journal of Dermatology” Carbamazepine may cause reversible nail detachment.
4 citations
,
December 2024 in “European Journal of Medicinal Chemistry” This study reported the development of new pyrazole-based MPC inhibitors that effectively inhibit mitochondrial pyruvate transport, showing potential as therapeutic candidates for conditions like metabolic dysfunction-associated steatohepatitis without activating PPARγ.
October 2023 in “JOJ dermatology & cosmetics” This study concluded that thiocyanate promotes new cell formation and hair growth in animals and humans, with therapeutic effects seen in 51% of human alopecia areata cases after treatment, attributed to diverse biological mechanisms.
June 2013 in “Clinical Neurophysiology” Finasteride improved reflexes and motor activity in rats with liver-related brain issues.
3 citations
,
August 2017 in “Synlett” This study reports a novel method for synthesizing substituted hydantoins, including the anticonvulsant drug ethotoin, using safer reagents and fewer steps compared to conventional protocols.
January 2025 in “Dusunen Adam The Journal of Psychiatry and Neurological Sciences”