Clinical Manifestations and Management of Acute Thallium Poisoning

The study retrospectively analyzed clinical information from 3 patients with acute thallium poisoning. All patients experienced severe burning pain in the lower limbs and abdomen, diffuse alopecia, hepatic dysfunction, and Mees’ lines on their digits within 2-3 weeks of onset. They also showed paresthesia in all limbs but had normal deep tendon reflexes. Elevated thallium levels were found in blood and urine. Treatment included hemoperfusion, hemodialysis, potassium and B complex supplementation, and oral laxatives, which improved symptoms as thallium levels decreased, though some sensory neuropathy persisted. The study highlighted gastrointestinal symptoms, polyneuropathy, and dermatological changes as primary manifestations of thallium poisoning, with hemoperfusion and hemodialysis as potential treatments.