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In this study, researchers used a hypospadiac rat model to demonstrate abnormal genital development, similar to human penoscrotal hypospadias, highlighting the model's value for studying penile growth and differentiation.

This case report highlights a novel NR5A1 gene variant associated with a severe 46,XY disorder of sex development, stressing the importance of genetic screening in similar cases.

In this case study, a 55-year-old male with a history of hypospadias repair developed urinary complications due to urethral hair bezoars, and the researchers reported that transcutaneous ND:YAG laser epilation effectively removed urethral hair, preventing recurrence of such issues.

This case report describes a 10-year-old twin boy with proximal hypospadias and undescended testis, highlighting the diagnostic and treatment evaluations for associated sex development disorders.

This review discusses the multifactorial etiology of hypospadias, including genetic predispositions and possible environmental factors, and highlights the need for further studies on genetic and environmental contributions to its increasing prevalence, without presenting new findings.

This review concludes that preoperative hormonal stimulation with testosterone or DHT may help increase penile length and glans circumference, easing hypospadias surgery and potentially reducing postoperative complications.

This review suggests that dihydrotestosterone pretreatment may improve cosmetic outcomes in hypospadias repair, but more randomized trials are needed to determine its effectiveness due to currently limited evidence.

This study found that hypospadias in male children is significantly associated with genetic polymorphisms in the Steroid 5 alpha reductase type 2 gene, higher parental age, consanguinity, rural residence, and preterm labor, with maternal age and rural residence being the strongest independent predictors.

Male infertility and genitourinary birth defects are often linked to genetic issues.

In this study of male patients with 46,XY 5α-reductase type 2 deficiency, DHT therapy was effective in achieving penile enlargement during infancy, while testosterone replacement therapy proved more beneficial during puberty, possibly due to increased conversion to DHT.

This review suggests that most mutations in the SRD5A2 gene show no clear genotype-phenotype correlation in 5-α-Reductase deficiency, although mutation location affects severity.

This review examines the diverse roles of SRD5α enzymes across species, focusing on their involvement in steroid synthesis, sexual development, and various physiological processes, but reports no new clinical results.

This review examined genetic factors in 46, XY differences/disorders of sex development and found that whole-exome sequencing is more effective than panel sequencing for molecular diagnosis. It identified regional genetic variation and emphasized next-generation sequencing's role in detecting variants related to gonadal and androgen-related genes.

This report discusses two pediatric cases of penile strangulation caused by maternal hair strands and emphasizes the need for swift diagnosis and treatment to prevent severe complications.

In this case report from People's College of Medical Sciences, a 20-year-old man initially misdiagnosed with Addison's disease was ultimately found to have strongyloidiasis, with his symptoms and weight loss improving after antihelminthic treatment.

This study found that dihydrotestosterone treatment may be more beneficial for height in children with 5-α-reductase type 2 deficiency compared to testosterone enanthate, especially in the prepubertal period.

This case report discusses the diagnostic challenges and management options for three siblings with 46, XY DSD due to type 2 5-α reductase deficiency, highlighting the genetic basis and impact on their quality of life.

This case study detailed a rare instance of Penile Thread Tourniquet Syndrome in a 10-year-old boy, where a thread caused localized infection and edema without urethral damage, ultimately resulting in a favorable outcome through surgical and conservative management.

This article reviews the development, classification, and embryology of hypospadias and reports no new findings; the authors highlight its unknown cause and discuss associated anatomical anomalies.

Using buccal mucosa for hypospadias repair in children is effective and reduces complications.

This study used micro-CT to visualize preputial vessel distribution in a congenital hypospadias rat model, revealing that vessels at the preputial junction with good circulation were well-suited for vascular pedicle flaps in surgery.

In this study, micro-CT analysis revealed that severe hypospadias in finasteride-induced rats was associated with varying levels of preputial blood circulation, impacting potential surgical approaches.

In this case report, a patient with pseudovaginal perineoscrotal hypospadias due to 5α-reductase deficiency presented gender dysphoria, and after genomic sequencing confirmation, injectable testosterone undecanoate treatment successfully developed desired male secondary sexual characteristics.

This study found that micro-CT imaging can effectively identify vascular structures in rat models of congenital hypospadias, providing anatomical insights for selecting preputial vessel flaps in surgical procedures.

This letter to the editor references a study on using dihydrotestosterone gel before hypospadias surgery but itself contains no new findings.

In this case report, the authors described how a 27-year-old male developed scarring and penile shortening after a previous lengthening procedure, which was successfully repaired using a pedicled superficial circumflex iliac artery perforator flap combined with a novel hybrid technique.

This case report describes a rare instance of multiple sebaceous cysts over the scrotum in a 22-year-old man, highlighting the effectiveness of ultrasound imaging for diagnosis and the need for surgical intervention in severe cases.

Flutamide-induced hypospadias in rats slows down early wound healing.

This case report describes an 8-year-old child with penile tourniquet syndrome due to a constricting thread, which led to partial distal penile amputation and required surgical intervention.

This case report highlights an 11-month-old boy with near total amputation of the glans penis due to Penile Hair Tourniquet Syndrome, who underwent successful two-stage surgical repair for a satisfactory outcome.