August 2024 in “Journal of Clinical Medicine” This review concludes that low-level laser therapy is the most supported physical treatment for androgenetic alopecia, but other therapies like nonablative laser treatments and combinations including PEMF may also be promising.
This review discusses various physical therapies for androgenetic alopecia, reporting that low-level laser therapy has the most evidence but highlighting other promising treatments, such as non-ablative lasers and multimodal approaches, that warrant further investigation.
July 2025 in “Carolina Digital Repository (University of North Carolina at Chapel Hill)” This review evaluated various physical treatments for androgenetic alopecia and highlighted that low-level laser therapy is well-supported by evidence. However, nonablative laser and multimodal approaches like PEMF-LLLT appear promising and warrant further investigation.
December 2024 in “Aesthetic Plastic Surgery” In this observational study, patients with androgenic alopecia or hair loss related to COVID-19 showed more significant hair regrowth when treated with combined pulsed electromagnetic field therapy and photobiostimulation therapy compared to photobiostimulation therapy alone, with a statistically significant increase in hair count.
March 2026 in “Frontiers in Cell and Developmental Biology” This review synthesizes evidence that photobiomodulation may provide robust symptomatic relief for knee osteoarthritis but indicates its potential for structural regeneration remains speculative and needs further long-term validation.
November 2022 in “Journal of Cosmetic Dermatology” In this study, combining photobiomodulation therapy and pulsed electromagnetic field therapy over 24 weeks significantly increased hair density in androgenetic alopecia patients compared to a sham device control, with minimal side effects reported.
April 2020 in “The Aesthetics” This article discusses the applications and proposed benefits of LED low level light therapy for various conditions like acne, wound healing, and pain relief, but provides no new clinical results.
2 citations
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January 2018 in “Recent clinical techniques, results, and research in wounds” This review discusses the effects of low-level laser therapy in various biological processes for wound healing and tissue repair and reports no new results.
433 citations
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April 2015 in “Photomedicine and laser surgery” This editorial discusses the terminology and distinctions between Low-Level Light/Laser Therapy and Photobiomodulation Therapy but reports no new clinical findings.
1057 citations
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November 2011 in “Annals of Biomedical Engineering” This review discusses the applications of low level laser therapy (LLLT) in wound healing, pain reduction, and treating various conditions, but reports no new clinical results; the authors highlight the need for randomized controlled trials for serious diseases.
June 2011 in “CRC Press eBooks” Low-Level Laser Therapy can stimulate healing and cell function, potentially leading to wider medical use.
12 citations
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October 2012 in “Dermatologic Clinics” This review discusses the use of electromagnetic radiation, including low-level laser therapy, for hair loss management, but it reports no new clinical results and suggests further research.
This study introduced a new laser-only method called EKA for acne treatment, which is reported to be safe, painless, and heat-free, showing promising results for both acne and scar repair in initial sessions without combining with LED light.
5 citations
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November 2014 in “Hair transplant forum international” This article introduces a series on low level laser light therapy, focusing on its science, regulatory aspects, and controlled trial methodologies, but reports no new clinical results.
160 citations
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December 2016 in “Journal of biophotonics” This review discusses the evolution and potential of photobiomodulation therapy, highlighting its transition from skepticism to recognition in medical research; it reports no new experimental findings.
December 2024 in “Surgery and Clinical Practice” This study suggests that Low-level Laser Therapy may improve pain and quality of life in women with Chronic Pelvic Pain Syndrome, though larger studies are needed to confirm these findings.
January 2012 in “Human health handbooks” This review discusses the application of low-level light therapy for hair loss treatment, particularly androgenetic alopecia, and reports no new clinical results; the authors suggest consideration of light source characteristics and potential pros and cons.
4 citations
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May 2015 in “Hair transplant forum international” The review concluded that better studies are needed to prove if Low-Level Laser Therapy devices for hair growth really work.
January 2017 in “Clinical approaches and procedures in cosmetic dermatology” This review explores clinical studies on low-level laser therapy (LLLT) for alopecia and suggests it may benefit patients unresponsive to conventional treatments, but larger studies are needed to confirm efficacy.
2 citations
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March 2021 in “Dermatologic Therapy” This study found that low-level laser therapy significantly increased hair counts in women with female pattern hair loss but not in those with telogen effluvium, without serious adverse events.
May 2019 in “Case medical research”
June 2001 in “Proceedings of SPIE” The authors concluded that low energy laser therapy may serve as a useful complementary treatment for skin diseases such as lichen planus, infectious finger pulpits, scalp alopecia, and crural ulcers.
February 2025 in “Journal of Biophotonics” This study found that using dual-wavelength low-level laser therapy is more effective for hair regrowth in mice than single-wavelength treatment and significantly better than no treatment, based on 14 days of phototherapy with LED lights.
March 2026 in “Frontiers in Immunology” In this study, a 49-year-old female with metastatic adrenocortical carcinoma experienced an abscopal effect following pulse electric field ablation, suggesting potential as an adjunct to systemic immunotherapy for liver tumors.
64 citations
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October 2020 in “Journal of lasers in medical sciences” This review discusses the benefits and drawbacks of low-level laser therapy for various non-surgical conditions based on existing literature, but reports no new clinical findings and suggests further research is needed.
This study found that low-level laser therapy may enhance wound healing and reduce pain, swelling, and inflammation by increasing mitochondrial activity and oxidative stress, leading to greater protein synthesis and cell proliferation.
4 citations
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September 2021 in “Medical Lasers” This review reports that low-level laser therapy may effectively prevent and alleviate oral mucositis from chemotherapy, supporting its use as a viable treatment option.
January 2006 in “Zhongguo linchuang jiepouxue zazhi” This study found that applying a low intensive pulse magnetic field significantly accelerated wound healing in rats by promoting the proliferation and differentiation of skin epidermal stem cells.
November 2021 in “Research Square (Research Square)” This study found that a 532 nm laser at 15 J/cm² enhanced the proliferation and differentiation of tendon-derived stem cells in rats, potentially accelerating tendon healing through the up-regulation of Nr4a1.