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Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

Hormonal therapy is effective for treating acne in adult women, especially with signs of high androgen levels.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Insulin sensitizers may slightly reduce hirsutism but are less effective than other treatments.

The document concludes that certain genetic mutations and dietary factors are involved in acne development, and treatments like isotretinoin and diet changes can help manage it.

Hormonal contraceptives can help treat acne by affecting sebum production and androgen levels.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

The document concludes that early diagnosis and treatment of Congenital Adrenal Hyperplasia are crucial for preventing serious health issues and improving patient outcomes.

Testosterone therapy seems safe for postmenopausal women for a few years, but more research is needed for long-term effects.

Androgens play a role in female sexual function, and testosterone therapy can help women with low sexual desire, but more research is needed on treatments and long-term safety.

New genes and pathways are important for testosterone production and male sexual development.

AMH helps estimate ovarian reserve but doesn't predict pregnancy chances; age is more important.

The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.

NcoA4 may have roles beyond helping control gene activity, possibly affecting cell behavior and stability.

The conclusion is that there is a high demand for new contraceptives that provide both pregnancy prevention and protection against STIs, along with additional health benefits.

Acne in children varies by age and severity, requires a pediatric treatment approach, and may need diagnostic evaluation for underlying conditions.

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

Acne vulgaris is a common skin condition that can cause low self-esteem and depression, and early treatment is important to prevent scarring.

Pubertal acne is linked to hormonal changes, affects quality of life, and is treated similarly to adult acne.

Testosterone replacement can help women with low libido and mood, but they need to have enough estrogen first to avoid side effects.

Certain ESR1 gene variations may affect hormone levels and fat distribution in women with high male hormone levels.

Certain drugs can reduce bladder muscle contractions, potentially helping treat bladder diseases.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Treating non-classic congenital adrenal hyperplasia is complex because the benefits of hormone treatment must be weighed against potential health risks.

Paris polyphylla saponins may effectively treat acne due to their antibacterial and anti-inflammatory properties.

Adult female acne is complex and requires a combination of treatments for effective management.

Metformin might help treat certain skin conditions, but more research is needed.