The Hidden Link Between Polycystic Ovary Syndrome and Kidney Stones: Findings From the Tehran Lipid and Glucose Study

    August 2023 in “ Diagnostics ”
    Marzieh Rostami Dovom, Maryam Rahmati, Saber Amanollahi Soudmand, Pardis Ziaeefar, Fereidoun Azizi, Fahimeh Ramezani Tehrani
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    TLDR Women with PCOS are more likely to develop kidney stones, especially those with certain PCOS types.
    The study "The Hidden Link between Polycystic Ovary Syndrome and Kidney Stones: Finding from the Tehran Lipid and Glucose Study (TLGS)" involved 520 women with Polycystic Ovary Syndrome (PCOS) and 1638 healthy women. It found that women with PCOS have a 59% increased risk of developing kidney stones compared to healthy women, with 12.5% of women with PCOS having a history of kidney stones, compared to 7.7% of healthy women. The risk was particularly high in women with PCOS Phenotype A and Phenotype D. The study suggests that microRNA expression disorders may be the underlying cause of both menstrual irregularities or polycystic ovaries and kidney stone formation in these women. However, further comprehensive longitudinal studies are recommended due to the lack of comprehensive assessment of kidney stones in this study.
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