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    Glossary Outer Root Sheath

    layer of cells surrounding and supporting the hair follicle

    The Outer Root Sheath (ORS) is a layer of cells that surrounds the hair follicle, providing structural support and playing a crucial role in the growth and cycling of hair. It extends from the epidermis down to the hair bulb and is involved in the regeneration of the hair follicle after shedding.

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    1. Role of the Wnt/β-Catenin Signaling Pathway in Mediating Outer Root Sheath Stem Cells to Promote Hair Follicle Regeneration and Skin Wound Healing in Mice Cells · 2026
    2. Keratins of the human hair follicle: “Hyperproliferative” keratins consistently expressed in outer root sheath cells in vivo and in vitro Differentiation · 1987 · 135 citations
    3. Basal cell carcinoma possibly originates from the outer root sheath and/or the bulge region of the vellus hair follicle Archives of Dermatological Research · 1999 · 107 citations
    4. Solid basal cell epithelioma (BCE) possibly originates from the outer root sheath of the hair follicle. PubMed · 1993 · 61 citations
    5. Outer root sheath keratinization in anagen and catagen of the mammalian hair follicle. A seventh distinct type of keratinization in the hair follicle: trichilemmal keratinization. PubMed · 1981 · 59 citations
    6. Pitx2, a β-catenin-regulated transcription factor, regulates the differentiation of outer root sheath cells cultured in vitro Journal of dermatological science · 2009 · 51 citations
    7. The chemotactic effect of a dermal papilla cell-derived factor on outer root sheath cells Journal of Dermatological Science · 2001 · 47 citations
    8. Localization of Minoxidil Sulfotransferase in Rat Liver and the Outer Root Sheath of Anagen Pelage and Vibrissa Follicles Journal of Investigative Dermatology · 1991 · 46 citations
    9. Wnt/β‐catenin and ERK pathway activation: A possible mechanism of photobiomodulation therapy with light‐emitting diodes that regulate the proliferation of human outer root sheath cells Lasers in Surgery and Medicine · 2017 · 43 citations
    10. Manipulation of outer root sheath cell survival perturbs the hair-growth cycle The EMBO Journal · 1999 · 37 citations
    11. Outer root sheath (ORS) cells organize into epidermoid cyst-like spheroids when cultured inside Matrigel: a light-microscopic and immunohistological comparison between human ORS cells and interfollicular keratinocytes Cell and Tissue Research · 1994 · 36 citations
    12. VEGF165 modulates proliferation, adhesion, migration and differentiation of cultured human outer root sheath cells from central hair follicle epithelium through VEGFR-2 activation in vitro Journal of Dermatological Science · 2013 · 35 citations
    13. Organotypic culture of outer root sheath cells from human hair follicles using a new culture device In Vitro Cellular & Developmental Biology - Plant · 1987 · 35 citations
    14. Effect of thioredoxin reductase 1 on glucocorticoid receptor activity in human outer root sheath cells Biochemical and Biophysical Research Communications · 2007 · 34 citations
    15. Experimental Modulation of the Differentiated Phenotype of Keratinocytes from Epidermis and Hair Follicle Outer Root Sheath and Matrix Cells Annals of the New York Academy of Sciences · 1991 · 31 citations
    16. VEGF upregulates VEGF receptor-2 on human outer root sheath cells and stimulates proliferation through ERK pathway Molecular Biology Reports · 2012 · 23 citations
    17. Double-stranded RNA induces inflammation via the NF-κB pathway and inflammasome activation in the outer root sheath cells of hair follicles Scientific reports · 2017 · 22 citations
    18. An osteopontin‐derived peptide inhibits human hair growth at least in part by decreasing fibroblast growth factor‐7 production in outer root sheath keratinocytes British Journal of Dermatology · 2019 · 19 citations
    19. miR-140-5p in Small Extracellular Vesicles From Human Papilla Cells Stimulates Hair Growth by Promoting Proliferation of Outer Root Sheath and Hair Matrix Cells Frontiers in cell and developmental biology · 2020 · 18 citations
    20. Pilomatricoma can differentiate not only towards hair matrix and hair cortex, but also follicular infundibulum, outer root sheath and hair bulge Experimental Dermatology · 2009 · 18 citations
    21. Epidermis reconstructed from the outer root sheath of human hair follicle. Effect of retinoic acid Archives of Dermatological Research · 1993 · 18 citations
    22. Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells Journal of Dermatological Science · 1994 · 16 citations
    23. Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles Pharmacological Reports · 2017 · 14 citations
    24. FORMATION OF A REGULAR NEO-EPIDERMIS BY CULTURED HUMAN OUTER ROOT SHEATH CELLS GRAFTED ON NUDE MICE Transplantation · 1995 · 14 citations
    25. Interferon β Secreted from Human Hair Dermal Papilla Cells Inhibits the Growth of Outer Root Sheath Cells Cultured in Vitro Biochemical and biophysical research communications · 2002 · 13 citations
    26. Progenitor cells expressing nestin, a neural crest stem cell marker, differentiate into outer root sheath keratinocytes Veterinary Dermatology · 2019 · 12 citations
    27. Sex Hormones and Antiandrogens Influence In Vitro Growth of Dermal Papilla Cells and Outer Root Sheath Keratinocytes of Human Hair Follicles. 1993 · 12 citations
    28. Expression of E6 and E7 papillomavirus oncogenes in the outer root sheath of hair follicles extends the growth phase and bypasses resting at telogen. PubMed · 2000 · 10 citations
    29. Effects of 1?,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsoriatic drugs Archives of dermatological research · 1993 · 10 citations
    30. Human Hair Outer Root Sheath Cells and Platelet-Lysis Exosomes Promote Hair Inductivity of Dermal Papilla Cell Tissue Engineering and Regenerative Medicine · 2020 · 9 citations