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Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The vitamin D receptor is crucial for bone health and affects various body systems, with mutations potentially leading to disease.

Polycystic Ovary Syndrome (PCOS) is a common condition in women that can cause metabolic, reproductive, and psychological issues, and requires lifestyle changes and medication for management.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Corticosteroids, especially prednisone, improve short-term muscle strength in Duchenne muscular dystrophy but have manageable side effects.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The document likely offers guidance on treating a woman's excessive hair growth, considering her symptoms and obesity.

The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Androgen deprivation therapy for prostate cancer can cause sexual, physical, and psychological side effects, and doctors should manage these carefully.

Biomaterials with MSC-derived substances could improve tissue repair and have advantages over direct cell therapy.

The Rotterdam Study aims to understand various diseases in older adults.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Oestrogens are key for bone growth during puberty in both boys and girls.

The peptide GHK-Cu helps heal and remodel tissue, improves skin and hair health, and has potential for treating age-related inflammatory diseases.

Testosterone therapy in transgender men has both desired effects like increased muscle mass and potential health risks such as higher cardiovascular risk.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Male pattern baldness involves genetics, hormones, and needs better treatments.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

Estrogens help reduce skin aging, and SERMs might offer similar benefits without the risks of hormone therapy.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

TSH is usually the only test needed to check thyroid function in primary care.