18 citations
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June 2016 in “PeerJ” In this study, testosterone increased the expression of epithelial sodium channel proteins and mRNAs in rat kidneys, suggesting a potential mechanism for its effect on blood pressure through enhanced sodium reabsorption.
February 2026 in “Andrology” This study highlights the need for a comprehensive andrological assessment at diagnosis, including semen and hormonal analysis, to guide fertility preservation strategies, and found that post-orchidectomy semen samples showed improved DNA integrity for assisted reproductive technologies.
4 citations
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January 2011 in “Dermatology” This case report describes a patient who developed localized hypertrichosis of the pinnae after undergoing orchiectomy and chemotherapy for testicular carcinoma.
January 2025 in “Seven Editora eBooks” In this study, the authors reported a case of alopecia X in a German Spitz dog and found that treatment with orchiectomy and melatonin resulted in partial hair regrowth and improved the dog's dermatological condition.
In this reported case, a male German Spitz diagnosed with alopecia X showed partial regrowth of alopecic areas after treatment with orchiectomy and melatonin, indicating this combination's potential effectiveness for the condition.
January 2025 in “LUMEN ET VIRTUS” In this study, a case of alopecia X in a male, uncastrated German Spitz dog was successfully managed with orchiectomy and melatonin, leading to partial hair regrowth and improved dermatological condition after 90 days of treatment.
This study found that bilateral orchiectomy allows most transgender women to stop anti-androgen medications, with 91.7% discontinuing them post-surgery and 25% reducing estrogen use.
2 citations
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December 2017 in “Theriogenology” This study found that V-ATPase plays a role in the acidification of vas deferens fluid under the influence of testosterone in orchidectomized rats.
11 citations
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September 2015 in “Theriogenology” Testosterone boosts fluid and electrolyte secretion in seminal vesicles, aiding sperm function.
9 citations
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January 2017 in “Archives of biochemistry and biophysics” In this study, testosterone was reported to increase aquaporin levels and water reabsorption in the kidneys of male rats, potentially leading to higher blood pressure, with effects mitigated by flutamide and finasteride.
6 citations
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November 2018 in “Journal of molecular histology” This animal study found that testosterone treatment increased vas deferens fluid secretion rate in rats, with potential implications for male fertility through the upregulation of AQP-1, 2, and 9 proteins.
October 2024 in “Journal of the Endocrine Society” This study observed that gender-affirming hormone therapy differentially affects metabolism in mice, with the specific metabolic impacts dependent on the type of hormonal treatment used.
13 citations
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February 2021 in “Brain Sciences” This study found that in adolescent male rats, androgens enhance inhibitory avoidance memory, possibly by interacting with androgen receptors in the amygdala and hippocampus.
5 citations
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January 2023 in “Fertility and sterility” This review discusses the emerging considerations and challenges of uterus transplantation for transgender women but presents no new clinical results.
3 citations
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June 2001 in “Journal of Zoo and Wildlife Medicine” This case study reported that after removal of an interstitial cell tumor from a ruffed lemur, the animal experienced improved coat quality and a return to normal behavior without signs of cancer spread.
1 citations
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November 2022 in “PubVet” This case study describes using microneedling combined with orchiectomy as a treatment for alopecia X in a male German Spitz dog, highlighting this approach for managing the condition.
September 2025 in “Medicine & Science in Sports & Exercise” In this rodent study, the researchers found that different hormone therapies affected gut microbiota and goblet cell counts, with notable microbial shifts observed between groups receiving estrogen with and without an orchiectomy, linked to estrogen metabolism.
October 2022 in “Journal of the ASEAN Federation of Endocrine Societies” This study found that GnRH-a treatment or orchiectomy, which required significantly lower doses of oral estradiol valerate, were more effective than anti-androgens like spironolactone and finasteride in achieving target hormone levels in transgender females in India.
July 2022 in “Research, Society and Development” This study observed variable therapeutic responses in dogs with Alopecia X, with some showing complete hair regrowth while others did not, following similar treatments including orchiectomy and supplementation.
April 2019 in “Journal of the Endocrine Society” This case study highlights the late diagnosis of complete androgen insensitivity syndrome in a 31-year-old woman, emphasizing the psychological impact and need for individualized treatment guidelines.
In a 14.5-year-old lemur, this study found that removing a testicle with an interstitial cell tumor improved coat quality and reduced aggression, with no signs of metastasis observed post-surgery.
1 citations
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October 2024 in “JCEM Case Reports” In this case report, a patient with pseudovaginal perineoscrotal hypospadias due to 5α-reductase deficiency presented gender dysphoria, and after genomic sequencing confirmation, injectable testosterone undecanoate treatment successfully developed desired male secondary sexual characteristics.
July 2019 in “Acta Scientiae Veterinariae” This case report describes a Canadian Husky dog with sertolioma that exhibited dermatological symptoms and aggressive behavior, both of which improved significantly after surgery.
May 2012 in “Reactions Weekly” A man developed hair loss from testosterone treatment but improved with additional medication.
30 citations
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July 2009 in “Experimental and clinical endocrinology & diabetes” This article reviews the use of cyproterone acetate for conditions like prostate cancer and sexual disorders, highlighting its effects on libido but reporting no new specific trial results.
April 2026 in “Veterinary Record Case Reports” In this case study, a 2-year-old Pomeranian dog from Mizoram, India, with alopecia X showed significant hair growth and improved skin condition after undergoing neutering and receiving omega-3 and omega-6 fatty acid supplements.
6 citations
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July 2011 in “British Journal of Dermatology” This paper reports a case of sebaceous carcinoma developing at the site of chronic candidiasis in a patient with keratitis–ichthyosis–deafness syndrome, without presenting new generalizable findings.
8 citations
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May 1996 in “Endocrinology” This study found that the androgen precursors DHEA and androstenedione stimulated androgen-sensitive parameters in the sebaceous glands of the skin in castrated male hamsters.
4 citations
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January 2002 in “Journal of Cosmetic Dermatology” This study found that long-pulsed ruby laser treatment effectively reduced hair density on the beard and chest of male-to-female transsexuals, achieving a 50–90% reduction maintained over six months.
226 citations
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September 2001 in “Journal of The American Academy of Dermatology” Hair loss in women is genetic, diagnosed by examination and biopsy, and treated with minoxidil, finasteride, or transplantation.