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Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

Melatonin may help with sleep issues, depression, and cancer, but more research is needed.

Lecithin organogels could be good for applying drugs to the skin because they are stable, safe, and can improve drug absorption.

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Myrtle has various health benefits and potential for medicine development.

Blocking COX, especially COX-2, in the skin can reduce inflammation and pain and may help prevent skin cancer.

The document concludes that adenosine receptor agonists have potential for treating various conditions, but only a few are approved due to challenges like side effects and the need for selective activation.

The conclusion is that PCOS is caused by ovarian sensitivity to hormones and disrupted hormone control, possibly due to ovarian factors, and more research is needed.

Eating disorders like anorexia and bulimia cause skin problems, and dermatologists can help detect these disorders early for better treatment outcomes.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Potassium channel openers are effective in treating heart conditions, high blood pressure, pulmonary diseases, bladder issues, and hair loss, but more selective drugs are needed.

Children with atopic dermatitis often have sleep problems, affecting their growth and behavior.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

Preoperative pain assessment, regional anesthesia, and vitamin C can help prevent CRPS after surgery.

Interferon, especially alfa interferon, is an effective treatment for cutaneous T-cell lymphoma with manageable side effects.

Prolactin affects hair growth and skin conditions, and could be a target for new skin disease treatments.

The genus Sophora has compounds with potential health benefits and could lead to new drugs, but more research is needed to understand their effects and safety.

Minoxidil boosts hair growth by targeting adenosine and possibly sulfonylurea receptor 2B.

Clomipramine may significantly reduce hair-pulling in Trichotillomania, but more research is needed on treatments and early onset cases.

Low-dose finasteride may cause lasting sexual dysfunction and suicidal thoughts in young men.

PCOS affects women's health by increasing the risk of diabetes, heart disease, and reproductive issues.

Men with coeliac disease may have hormone imbalances that could affect sexual function, but these can improve with better gut health.

Beta-caryophyllene helps improve wound healing in mice, especially in females.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

ADT, especially enzalutamide, may increase the risk of heart rhythm problems and sudden death in men.

The cause of Frontal Fibrosing Alopecia is unclear, diagnosis involves clinical evaluation and various treatments exist, but their effectiveness is uncertain.

There are still challenges in diagnosing and treating chronic skin diseases, but there is hope for future improvements.

Products should be called 'sperm-safe' only after thorough, well-designed tests.