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    Glossary Off-label Use

    prescribing medication for an unapproved condition or dosage

    Off-label use refers to the practice of prescribing a medication for a purpose that has not been officially approved by regulatory agencies like the FDA. This can include using the drug to treat a different condition, in a different dosage, or in a different patient population than what is specified in the approved labeling. While off-label use is legal and can be based on sound medical evidence, it often requires careful consideration and professional judgment.

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    1. Off-Label Use of Topical Minoxidil in Alopecia: A Review American Journal of Clinical Dermatology · 2019 · 32 citations
    2. Off-Label Uses of Topical Vitamin D in Dermatology: A Systematic Review Journal of cutaneous medicine and surgery · 2014 · 26 citations
    3. Off-Label Uses of Abrocitinib: Review of Emerging Therapeutic Applications beyond Atopic Dermatitis Life · 2024 · 10 citations
    4. Off-label uses of retinoids in dermatology Our Dermatology Online · 2012 · 6 citations
    5. Off-Label Use of Botulinum Toxin in Dermatology—Current State of the Art Molecules · 2022 · 5 citations
    6. Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review Archives of Dermatological Research · 2025 · 3 citations
    7. Off‐Label Use of Topical Ruxolitinib in Dermatology: A Systematic Literature Review and Current Perspectives Experimental Dermatology · 2025 · 1 citations
    8. Off-label dermatologic uses of IL-23 inhibitors Journal of Dermatological Treatment · 2024 · 2 citations
    9. Off Label Medication and Use of Unapproved Drugs 2016
    10. The Off-Label Use of Selective Serotonin Reuptake Inhibitors for Sexual Behavior Management: Risks and Considerations Healthcare · 2025
    11. Botulinum Toxin Off-Label Use in Dermatology: A Review Skin appendage disorders · 2017 · 53 citations
    12. 13777 The off-label use of spironolactone in female pattern hair loss Journal of The American Academy of Dermatology · 2020 · 1 citations
    13. Review of Promising Off-Label Use of Deucravacitinib International Journal of Molecular Sciences · 2025
    14. Evidence for the off-label use of tofacitinib in alopecia areata Scientific Electronic library online (Sciences Carlos III Health Institute) · 2025
    15. The pattern of off-label and unlicensed drug use in adult and pediatric patients in the Kingdom of Saudi Arabia: multicenter retrospective study International Journal of Community Medicine and Public Health · 2019 · 3 citations
    16. BH09 Patient experience of off-label Janus kinase inhibitor use for alopecia areata in a cohort of 34 patients from a single UK practitioner: exploring changing trends in healthcare provision and access to drug treatments 2023
    17. Social Interest Data as a Proxy for Off-Label Performance-Enhancing Drug Use: Implications and Clinical Considerations Curēus · 2024 · 1 citations
    18. Dupilumab: A Review of Present Indications and Off-Label Uses Journal of investigational allergology & clinical immunology · 2021 · 50 citations
    19. Tacrolimus ointment: summarizing two decades of experience in off-label use. Use in rosacea, seborrheic dermatitis, papulosquamous dermatoses, lupus erythematosus, eczematous dermatoses, alopecia, and other diseases Vestnik dermatologii i venerologii · 2026
    20. Facial hair enhancement with minoxidil—an off-label use SAGE Open Medical Case Reports · 2024
    21. (423) A Case Series of Successful Off-label Use of Flibanserin The Journal of Sexual Medicine · 2023
    22. Comparison of minoxidil sulfotransferase activity between scalp hair, eyebrows, and eyelashes: Implication for minoxidil efficacy for off‐label use Journal of cosmetic dermatology · 2024
    23. Entrepreneurship in Off-Label Drug Prescription: Just What the Doctor Ordered! Social Science Research Network · 2015 · 3 citations
    24. Off-label prescriptions: patient safety first The Lancet Oncology · 2011 · 4 citations
    25. Off-label Prescription and Challenges in Clinical Practice: An Abridged Review Current trends in diagnosis & treatment · 2020
    26. Controversies in off‐label prescriptions in dermatology: the perspective of the patient, the physician, and the pharmaceutical companies International Journal of Dermatology · 2018 · 8 citations
    27. Safety and tolerability of low-dose oral minoxidil in adolescents: A retrospective review Journal of the American Academy of Dermatology · 2022 · 2 citations
    28. Impact of a health alert and its implementation on flutamide prescriptions for women: an interrupted time series analysis BMC Health Services Research · 2020 · 2 citations
    29. Prescribing to save patients money: Ethical considerations Journal of The American Academy of Dermatology · 2018 · 2 citations
    30. Bicalutamide: A review Journal of Cutaneous and Aesthetic Surgery · 2024