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Cyclosporin doesn't stop hair loss.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

The document concludes that understanding how the skin's immune system and inflammation work is complex and requires more research to improve treatments for skin diseases.

Epithelial stem cells are crucial for tissue renewal and repair, and understanding them could improve treatments for damage and cancer.

Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Anabolic steroids can build muscle and strength but have risks and need more research on their clinical benefits and side effects.

African spiny mice can regenerate skin, hair, and cartilage, but not muscle, and their unique abilities could be useful for regenerative medicine.

Targeting colon cancer stem cells might lead to better treatment results.

Some wound-healing cells can turn into fat cells around new hair growth in mice.

Understanding phenotypic plasticity is crucial for developing effective cancer therapies.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

β-catenin is essential for stem cell activation and proliferation in hair follicles.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.

Lgr5 is a marker for active, self-renewing stem cells in the intestine and skin, important for tissue maintenance.

Super-enhancers controlled by pioneer factors like SOX9 are crucial for stem cell adaptability and identity.

Changing how mesenchymal stromal cells are grown can improve their healing abilities.

Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.

Anticancer drugs are increasingly found in surface waters, and their long-term environmental effects are not well understood, requiring better testing methods.

Increasing mir-302 turns human hair cells into stem cells by changing gene regulation and demethylation.

The research found that different types of fibroblasts are involved in wound healing and that some blood cells can turn into fat cells during this process.

The conclusion is that using drugs to block the TOR pathway might slow aging and prevent age-related diseases.