8 citations,
May 2018 in “The Journal of Allergy and Clinical Immunology” Activating the Nrf2 pathway reduces inflammation and cell activation in human hair follicles, suggesting a potential treatment for certain hair loss conditions.
January 2015 in “International Journal of Trichology” Lithium can treat bipolar disorder but may cause hair loss and other hair problems.
January 2010 in “The Year book of perinatal/neonatal medicine” Early skin biopsy helps diagnose and manage severe skin conditions in babies.
159 citations,
December 2007 in “American Journal of Pathology” Stress-related substance P may lead to hair loss and negatively affect hair growth.
95 citations,
December 1980 in “The New England Journal of Medicine” Minoxidil helped bald patient regrow hair.
66 citations,
July 2007 in “Journal of Molecular Medicine” Stress increases certain chemicals in the skin and nerves, which might worsen skin conditions.
32 citations,
July 2017 in “Dermatology practical & conceptual” New hair and skin changes were found in a rare case of syphilis-related hair loss.
27 citations,
July 2008 in “Neuroscience” Finasteride given to baby rats causes anxiety-like behavior and worsens learning from punishment in adult rats.
24 citations,
January 2003 in “Journal of Investigative Dermatology” Blocking a specific receptor slows down hair loss in mice.
11 citations,
January 2016 in “Bipolar Disorder” Valproate is a mood stabilizer for bipolar disorder but has side effects and risks, especially during pregnancy.
6 citations,
April 2013 in “International Journal of Dermatology” Valproic acid helped hair growth in alopecia patient; more research needed.
2 citations,
July 1999 in “Liver transplantation and surgery” Liver transplant can lead to neurological, pulmonary, cardiovascular, and renal complications, with older patients facing higher risks.
1 citations,
January 2014 in “Progress in Neurology and Psychiatry” Skin diseases can cause psychological issues, and better integration of dermatology and psychiatry is needed to improve patient care.
July 1999 in “Liver transplantation and surgery” Oxygen levels can drop during liver transplant if bypass pressures are too high, but other reasons should be checked first.
271 citations,
May 2019 in “Cells” The secretome from mesenchymal stem cells is a promising treatment that may repair tissue and avoid side effects of stem cell transplantation.
128 citations,
August 2015 in “Cell Stem Cell” Damage to skin releases dsRNA, which activates TLR3 and helps in skin and hair follicle regeneration.
108 citations,
July 2004 in “American Journal of Pathology” Stress increases a factor in mice that leads to hair loss, and blocking this factor may prevent it.
91 citations,
December 2010 in “Stem Cells” Wnt signaling helps control how brain stem cells divide and is important for brain repair after injury.
84 citations,
July 2003 in “European journal of biochemistry” Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.
76 citations,
March 2005 in “Journal of Molecular Medicine” Certain mice without specific receptors or mast cells don't lose hair from stress.
64 citations,
March 2005 in “Journal of Investigative Dermatology” Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.
63 citations,
December 1988 in “International Journal of Dermatology” Vitiligo causes white skin patches and is linked to autoimmune issues.
61 citations,
September 2008 in “Biological & Pharmaceutical Bulletin” Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.
48 citations,
July 1996 in “Human & Experimental Toxicology” Human enzymes can detoxify harmful substances but might also increase their cancer risk.
47 citations,
January 2019 in “Nature communications” Polyamines help fix DNA damage accurately in cells.
31 citations,
April 2010 in “British journal of dermatology/British journal of dermatology, Supplement” Frontal fibrosing alopecia can cause sudden hair loss on limbs, similar to scalp hair loss.
29 citations,
March 2012 in “Stem Cell Research & Therapy” Some stem cells in the body rarely divide, which could help create better treatments for diseases and aging.
27 citations,
May 2015 in “Neuropharmacology” Dutasteride protects dopamine neurons in Parkinson's mice, but Finasteride doesn't.
26 citations,
January 2017 in “Acta dermato-venereologica” Antidepressants might help with skin inflammation and improve conditions like psoriasis and eczema.
26 citations,
August 2006 in “Journal of Clinical Pharmacy and Therapeutics” Some patients lost hair after being treated with the drug enoxaparin for a brain vein clot.