Bipolar Disorders and Valproate: Pharmacokinetics, Pharmacodynamics, Therapeutic Effects, and Indications of Valproate: Review of Articles

    January 2016 in “ Bipolar Disorder ”
    Getinet Ayano
    Image of study
    TLDR Valproate is a mood stabilizer for bipolar disorder but has side effects and risks, especially during pregnancy.
    Valproate was a mood stabilizer approved for acute and maintenance treatment of mania in bipolar disorder, particularly effective for rapid cycling, irritable mania, and severe mania with psychosis. Its exact mechanism was unknown but involved enhancing brain GABA levels and modulating various neurotransmitters and channels. Common side effects included GI distress, tremor, sedation, hair loss, increased appetite, and weight gain, with rare serious effects like hepatic failure and pancreatitis. Valproate posed an increased risk of fetal abnormalities during pregnancy and interacted with several other medications, affecting its concentration levels. Routine blood level monitoring was not necessary.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 18 results

      community Better Than Minoxidil? Topical Sodium Valproate

      in Research/Science  53 upvotes 2 months ago
      Topical sodium valproate may promote hair growth by inhibiting GSK3β, allowing beta-catenin to proliferate, but it has potential side effects and requires more research. The conversation also mentions skepticism about a product called Vdphlo1, which includes sodium valproate and other ingredients.

      community New & Improved Hair Growth Stack for Maximum Results

      in Treatment  2 upvotes 2 months ago
      A user shared a hair growth stack using minoxidil sulfate, valproic acid, bimatoprost, blue copper peptide, and other ingredients, emphasizing a gel-based formula for better skin tolerance. Another user suggested adding a 5-alpha-reductase inhibitor like finasteride or dutasteride for more effective long-term results.

      community 6 months before and after pics: VDPHL01 (oral minoxidil)

      in Progress Pictures  110 upvotes 1 month ago
      A user shared their positive experience with a clinical trial for a new oral medication, VDPHL01, which is a reformulated version of oral minoxidil taken at a high dose of 17mg daily, showing significant hair regrowth after six months. The user noted that this formulation is believed to be more effective and time-released, with fewer side effects compared to regular oral minoxidil.

      community Found the solution tressbros - 1.5 years 2.5mg oral minox, 5mg finasteride, 8mg estradiol valerate (weekly)

      in Transgender  591 upvotes 1 year ago
      The conversation discusses a transgender individual's successful hair loss treatment over 1.5 years using 2.5mg oral minoxidil, 5mg finasteride, and 8mg weekly injectable estradiol valerate. Some users debate the appropriateness of this approach within the group's goals, while others support the individualized treatment and its additional benefits for transgender individuals.

    Similar Research

    5 / 677 results