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    Glossary Nerve Regeneration

    process where damaged neurons repair and restore their function

    Nerve regeneration, also known as nerve repair or neural regeneration, is the process by which damaged nerve cells (neurons) repair themselves and restore their function. This involves the regrowth of axons, the long thread-like parts of neurons, and the re-establishment of connections with other neurons or target tissues. While peripheral nerves have some capacity for regeneration, central nervous system nerves (like those in the brain and spinal cord) have limited ability to heal, making research in this area crucial for treating injuries and neurodegenerative diseases.

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    1. The use of keratin biomaterials derived from human hair for the promotion of rapid regeneration of peripheral nerves Biomaterials · 2007 · 309 citations
    2. Human hair follicle pluripotent stem (hfPS) cells promote regeneration of peripheral‐nerve injury: An advantageous alternative to ES and iPS cells Journal of Cellular Biochemistry · 2009 · 121 citations
    3. Concise Review: Tissue-Engineered Skin and Nerve Regeneration in Burn Treatment Stem Cells Translational Medicine · 2013 · 84 citations
    4. A Human Hair Keratin Hydrogel Scaffold Enhances Median Nerve Regeneration in Nonhuman Primates: An Electrophysiological and Histological Study Tissue Engineering Part A · 2013 · 69 citations
    5. Augmenting Peripheral Nerve Regeneration Using Rat Hair Follicle Stem Cells (rHFSCs) in Rats Basic and Clinical Neuroscience Journal · 2021 · 4 citations
    6. [Mechanism of rat sciatic nerve regeneration induced by human hair keratin]. PubMed · 2008 · 1 citations
    7. Regeneration of Peripheral Nerves Using Neuroinductive Biomaterial Scaffolds WakeSpace (Wake Forest University) · 2009 · 1 citations
    8. Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p Mendeley Data · 2026
    9. CuCS/Cur composite wound dressings promote neuralized skin regeneration by rebuilding the nerve cell "factory" in deep skin burns Materials today bio · 2024
    10. Tissue‐engineering approaches to enhance nerve regeneration during wound healing The FASEB Journal · 2006
    11. 4-Aminopyridine Induces Nerve Growth Factor to Improve Skin Wound Healing and Tissue Regeneration Biomedicines · 2022
    12. Nerve dependence in tissue, organ, and appendage regeneration Trends in Neurosciences · 2012 · 228 citations
    13. Regeneration of skin appendages and nerves: current status and further challenges Journal of Translational Medicine · 2020 · 71 citations
    14. Induced pluripotent stem cell–derived mesenchymal stem cells enhance acellular nerve allografts to promote peripheral nerve regeneration by facilitating angiogenesis Neural Regeneration Research · 2024 · 10 citations
    15. Experimental dataset for: Hair follicle neural crest stem cell-derived exosomes promote peripheral nerve regeneration via miR-214-3p Mendeley Data · 2026
    16. Human Hair Derived Keratins Mediate Schwann Cell Behavior in vitro and Facilitate Rapid Peripheral Nerve Regeneration in vivo ˜The œFASEB journal · 2007
    17. Nerve-mediated expression of histone deacetylases regulates limb regeneration in axolotls Developmental Biology · 2019 · 12 citations
    18. How Advancing is Peripheral Nerve Regeneration Using Nanofiber Scaffolds? A Comprehensive Review of the Literature International Journal of Nanomedicine · 2023 · 13 citations
    19. Motoneuron-Specific PTEN Deletion in Mice Induces Neuronal Hypertrophy and Also Regeneration after Facial Nerve Injury 2022 · 6 citations
    20. 1334 Beyond goosebumps: Interactions between the hair follicle, the arrector pili muscle, and the sympathetic nerve during development and hair follicle regeneration Journal of Investigative Dermatology · 2018
    21. Human hair keratins promote the regeneration of peripheral nerves in a rat sciatic nerve crush model Journal of Materials Science Materials in Medicine · 2019 · 36 citations
    22. Keratin Gel as Conduit Filler for Peripheral Nerve Regeneration on a Rat Sciatic Nerve Injury Model 2010
    23. Ultrasound-Activated GelMA Hydrogel Loaded with MSC-EVs Promotes Functional Regeneration of Skin Vasculature, Nerves, and Appendages ACS Applied Materials & Interfaces · 2025
    24. Ultrasound-ActivatedGelMA Hydrogel Loaded with MSC-EVsPromotes Functional Regeneration of Skin Vasculature, Nerves, andAppendages OPAL (Open@LaTrobe) (La Trobe University) · 2025
    25. The concept of tissue regeneration: Epistemological and historical enquiry from early ideas on the regeneration of bone to the microscopic observations of the regeneration of peripheral nerves Frontiers in Cell and Developmental Biology · 2022 · 3 citations
    26. Keratin Biomaterials Activate Schwann Cells via Integrin‐Mediated Signaling and Promote Regeneration of Large Peripheral Nerve Defects in a Rabbit Model The FASEB Journal · 2009
    27. Nestin‐positive hair follicle pluripotent stem cells can promote regeneration of impinged peripheral nerve injury The Journal of Dermatology · 2011 · 57 citations
    28. Intracavernous injection of platelet‐rich plasma reverses erectile dysfunction of chronic cavernous nerve degeneration through reduction of prostate hyperplasia evidence from an aging‐induced erectile dysfunction rat model The FASEB Journal · 2023 · 12 citations
    29. Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves Proceedings of the National Academy of Sciences · 2005 · 319 citations
    30. The effect of human hair keratin hydrogel on early cellular response to sciatic nerve injury in a rat model Biomaterials · 2013 · 105 citations