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Clouston's syndrome is a rare disorder affecting nails, hair, teeth, and skin, caused by a gene mutation, and currently has no treatment, only supportive care.

Pathologic tissues have more soluble proteins than normal tissues.

A child with ectodermal dysplasia-syndactyly syndrome has a new mutation in the NECTIN4 gene.

Rituximab may be an effective treatment for Cronkhite-Canada syndrome with kidney disease.

Soy supplements improve various skin conditions and aging signs, with topical use boosting skin barrier function.

Muttaijow ComplexTM improved skin, hair, and nail health in middle-aged adults.

Human hair keratins K85 and K35 create unique filament patterns important for early hair formation.

Skin problems are very common in people with end-stage kidney disease.

Nail stem cells and Wnt signaling are important for fingertip regeneration but not sufficient for regenerating more complex limb structures.

PDE inhibitors, especially PDE4 inhibitors like apremilast, are effective for certain inflammatory skin conditions but have side effects and can be costly.

Patients with chronic graft-versus-host disease often have skin problems like vitiligo and alopecia areata.

Mutations in the KRT85 gene cause hair and nail problems.

WNT10A mutations cause varied symptoms in patients with odonto-onycho-dermal dysplasia.

L-Cystine and L-Cystine with Kera-Diet® safely improved hair and nail quality in healthy women.

Cystatin M/E helps in the final stages of hair and nail formation by controlling certain enzymes.

Hair and nails are similar keratin structures with different shapes and growth, affected by the same diseases and environmental factors.

Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.

Mutations in the P2RY5 gene cause autosomal recessive woolly hair.

Different combinations of human hair keratins affect how hair fibers form.

Taking choline-stabilized orthosilicic acid orally significantly improved hair, skin, and nail health without side effects.

Recognizing certain rashes can lead to earlier cystic fibrosis diagnosis and better outcomes.

Toxic shock syndrome is caused by a complex interaction of bacterial toxins and the immune system, and understanding this can help improve diagnosis and treatment.

The protein p53 directly reduces the production of Keratin 17, a skin and hair protein, in rats with radiation dermatitis.

Skin side effects from EGFR inhibitor cancer treatment can be managed effectively, often without stopping the medication.

Wearing a frozen glove during chemotherapy can reduce nail and skin problems but may not be comfortable for everyone.

A specific mutation in the K25 gene causes a rare genetic disorder with curly hair at birth and later hair loss, along with dental issues.

AIRE protein, defective in APECED patients, is found in skin and hair cells and interacts with cytokeratin 17.

The document concludes that the human keratin gene cluster is complex, with a need for updated naming to reflect over 50 functional genes important for hair and skin biology.

Autophagy changes the protein makeup of hair.

Online medical education helps doctors make better clinical decisions and increases their knowledge in treating fungal nail infections.