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This narrative review compiled evidence suggesting that microneedling can effectively and safely improve skin conditions like scars, hyperpigmentation, and aging, provided it is performed correctly, by stimulating collagen production and enhancing topical treatment penetration.

In this study, researchers developed microparticle-embedded gas-propelled microneedles that showed higher drug loading and transdermal delivery efficiency compared to traditional microneedles.

This review found that microneedling appears to be a safe and effective option for treating scars and wrinkles, with fewer side effects and shorter recovery time than some other treatments.

This paper presents a new methodology combining magnetic tweezers and traction force microscopy to study keratinocyte mechanobiology, but reports no experimental results yet.

This article discusses current visualization methods for assessing hair restoration therapy responses, noting imprecision in triangulated measurements and patient dissatisfaction with visible tattoos.

This essay reviews the potential of protein microarrays in proteomics and diagnostics, highlighting no new clinical results but emphasizing the need for advanced high-quality proteins and antibodies.

This study observed that repeated low-depth microneedling in patients with androgenetic alopecia led to initial hair improvement but subsequently caused hair-shaft fragility and breakage, suggesting iatrogenic damage.

This study concluded that allele-specific PCR (AS-PCR) is more reliable than tetra-primer ARMS-PCR for genotyping the SNP rs1998076 due to better stability and interpretability.

This review discusses the development and application of multiphoton microscopy in dermatology, highlighting its advantages and potential future research directions without reporting new clinical results.

This study conducted a comprehensive analysis of methods for assessing surface roughness, highlighting that contact methods using profilometers provide accurate results for machine parts, while non-contact optical and laser methods offer high precision and efficiency without damaging surfaces.

This review highlights that two-photon excitation microscopy is a valuable tool for visualizing live skin structures and immune responses at high resolution, though its clinical use is hindered by safety and cost issues.

This abstract provides no specific research findings; it appears to contain journal subscription information and other non-research content.

This research found that modifying brachytherapy seeds with contrast-enhancing materials in photoacoustic imaging increased signal-to-noise ratios and imaging depth, and demonstrated potential for tissue differentiation by analyzing temperature-induced changes in PA intensity.

This review provides guidance on using two-photon microscopy for real-time and long-term visualization of stem cell activity in live mice skin, focusing on its application in researching skin and stem cell biology.

This study used novel methods to detect and map iodine concentrations in pig skin, finding iodine present in the coating, stratum corneum, and tissue around hair follicles.

This study found that finite element analysis-guided design improved bubble microneedles' controlled tip separation and insertion strength, supporting effective transdermal and sublingual drug delivery.

This literature review reports that micro-needle radiofrequency is increasingly recognized in aesthetic medicine as a safe, effective treatment for various skin conditions, but further research is needed to optimize treatment parameters for the best outcomes.

This paper details a method for measuring testosterone metabolism into seven androgens using digital autoradiography, which offers high sensitivity and reduces the need for radioactive materials.

This study developed an ultrahigh-power sonicator to improve protein extraction from hair shafts, followed by advanced proteomic analysis, identifying 239 differentially expressed proteins in fetal growth restriction cases compared to healthy controls, which were validated as potential biomarkers for perinatal diagnostics.

This study found that skin surface lipids contain measurable mRNAs, providing a non-invasive way to study skin diseases, with specific gene expression changes observed in atopic dermatitis patients.

This review summarizes the use of 3D printing technologies for creating microneedles and evaluates their associated benefits, challenges, and regulatory considerations, but does not present new experimental results.

This study demonstrates that the newly developed portable reflectance confocal microscope (PRCM) offers real-time, noninvasive monitoring of wound healing processes by visualizing skin morphology in both mice and humans.

This study reported that mSKPs and DMSCs share similarities in biological characteristics but exhibit distinct transcriptome profiles, with mSKPs being more immune-related and DMSCs more associated with differentiation and disease pathways.

This article reviews microneedle technology as a transdermal drug delivery platform without presenting new clinical results, emphasizing its engineered microstructure arrays for enhanced penetration.

This study developed a co-design framework using finite element analysis to optimize bubble microneedles, achieving controlled tip separation and effective drug delivery through the skin and mucosa while maintaining insertion strength.

This study reports that a new DART-HRMS method can effectively analyze intact hair for drug use timelines, with cocaine detection aligning with forensic standards and identifying multiple drugs from high-resolution data.

This study describes a new intravital microscopy method for observing intestinal regeneration by tracking crypt dynamics in living mice after laser-induced tissue damage, revealing events like crypt fission, fusion, and disappearance over multiple weeks.