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Glossary Methylisothiazolinone

powerful preservative in personal care products, can cause allergies

Methylisothiazolinone (MIT) is a powerful preservative commonly used in personal care products, such as shampoos and conditioners, to prevent the growth of bacteria and fungi. While effective at preserving product integrity, it has been associated with allergic reactions and skin sensitivities, leading to its restricted use in some formulations.

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research Contact Dermatitis Associated With Nail Care Products: Retrospective Analysis of North American Contact Dermatitis Group Data, 2001–2016

33 citations , April 2020 in “Dermatitis”

This study found that 9% of tested patients had positive patch test reactions linked to hair care products, with most reactions clinically relevant and commonly involving allergens like p-phenylenediamine.

research Allergen Content of Best-Selling Ethnic Versus Nonethnic Shampoos, Conditioners, and Styling Products

10 citations , December 2020 in “Dermatitis”

This study identifies important differences in allergens found in hair products marketed for ethnic hair compared to nonethnic hair, with fragrances being the most common allergen in ethnic products.

research Allergic Contact Dermatitis of the Scalp Associated With Scalp Applied Products: A Systematic Review of Topical Allergens.

5 citations , July 2022 in “PubMed”

This study identified the most common allergens in hair products linked to scalp allergic contact dermatitis, with hair dyes, shampoos, and conditioners primarily associated with the condition.

research Allergic Contact Dermatitis Associated With Men’s Personal Care Products: A Review of Allergens

November 2024 in “Dermatitis”

This review identifies specific personal care products and allergens commonly causing allergic contact dermatitis in men, which may improve diagnosis and treatment.

research Contact Dermatitis

May 2023 in “Australasian Journal of Dermatology”

Results are not reported in this source. The abstract does not provide a summary or findings from the Australasian Journal of Dermatology regarding contact dermatitis.

Comparison of Formulation and Allergenic Potential of Clean and Traditional Shampoos

research Comparison of the formulation and allergenic potential of “clean” and traditional shampoos

October 2022 in “Journal of the American Academy of Dermatology”

This study found that "clean" shampoos are less likely to contain allergenic preservatives compared to traditional shampoos, but both types use fragrance equally, which can be irritating or allergenic.

research Cosmetovigilance in The Netherlands : Overview of the period 2009-2014

February 2015 in “Rivm (National Institute for Public Health and the Environment)”

This report summarizes data from The Netherlands' cosmetovigilance system from 2009-2014, finding that facial and hair products commonly caused undesirable skin reactions like erythema and itching, with severe cases occasionally involving hair loss and respiratory issues.

Atypical or Severe Contact Eczema from Cinnamon Essential Oil

research Eczémas de contact atypiques ou sévères à l’huile essentielle de cannelle

November 2013 in “Annales de Dermatologie et de Vénéréologie”

This study found that extracts of Punica granatum L. improved hair growth and demonstrated significant anti-lice and antidandruff activity in a mouse model.

research Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

20 citations , June 2022 in “Molecules”

This review discusses three classes of thiazole-bearing compounds in drug development and presents preclinical findings but reports no new experimental results, highlighting the need for further drug discovery.

Dermatological Drugs and Cosmetics: Allergenic and Adverse Effects

research Dermatological drugs and cosmetics

January 1987 in “Side effects of drugs annual”

This chapter reviews dermatological drugs and cosmetics, identifying common allergens and preservatives linked to contact dermatitis without reporting new clinical results.

research Allergic contact dermatitis to topical brimonidine

6 citations , July 2015 in “Australasian Journal of Dermatology”

A man developed an allergic skin reaction after using brimonidine for rosacea.

research An Unusual Case of Contact Dermatitis

5 citations , January 2017 in “Skin appendage disorders”

In this case report, the authors linked acute psoriasiform contact dermatitis of the forehead and scalp to a low-laser light cap, identifying DMDE in the fabric as a likely cause.

research Iododerma in pregnancy secondary to iodinated multivitamins

3 citations , July 2015 in “Australasian Journal of Dermatology”

This letter discusses a case of iododerma in pregnancy linked to iodinated multivitamin use, but reports no new clinical findings.

research Shampoos: Ingredients, efficacy and adverse effects

67 citations , April 2007 in “Journal der Deutschen Dermatologischen Gesellschaft”

This article reviews the development and formulation of shampoos, emphasizing their dual role as cosmetic and medicinal products, but presents no new experimental findings.

research Dupilumab: A Review of Present Indications and Off-Label Uses

50 citations , March 2021 in “Journal of investigational allergology & clinical immunology”

This review examines existing research and clinical trials on the use of dupilumab for various skin, respiratory, and gastrointestinal disorders, but it reports no new clinical findings.

research Skin diseases associated with atopic dermatitis

43 citations , June 2018 in “Clinics in dermatology”

This review discusses the variety of skin disorders associated with atopic dermatitis, exploring their complex relationships and shared genetic and environmental factors, but reports no new clinical results.

A Primer on Cosmetics for Dermatologists

research A primer on cosmetics

34 citations , September 1992 in “Journal of the American Academy of Dermatology”

This article provides dermatology residents with essential information on cosmetic use to help manage skin conditions and reactions, without reporting new clinical results.

research Hair Cosmetics: Dyes

21 citations , October 2014 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas”

This review discusses the role of hair dyes in cosmetic dermatology, their effects on hair and scalp health, and the importance of dermatologists understanding potential side effects; it reports no new findings.

research Pustular allergic contact dermatitis caused by fragrances

19 citations , February 2015 in “Contact dermatitis”

Avoiding certain fragrances improved the man's skin condition.

research Common Allergens Identified Based on Patch Test Results in Patients with Suspected Contact Dermatitis of the Scalp

16 citations , December 2016 in “Skin appendage disorders”

This study analyzed patch test results to identify allergens causing scalp contact dermatitis, finding nickel, cobalt, and balsam of Peru among the most common in the patient population.

Effects of a New Mild Shampoo for Preventing Hair Loss in Asians Using a Simple Hand-Held Phototrichogram Technique

research Effects of a new mild shampoo for preventing hair loss in Asian by a simple hand-held phototrichogram technique

9 citations , June 2011 in “International Journal of Cosmetic Science”

This study found that a commercially available shampoo significantly increased hair counts and reduced hair shedding in Korean subjects with alopecia over 16 weeks.

research Structural changes of hair shaft after application of chemical hair straighteners: Clinical and histopathological study

7 citations , August 2018 in “Journal of cosmetic dermatology”

This study found that chemical hair straightening significantly reduced hair curl and improved smoothness and shine, but did not significantly affect transverse fissures or split ends, indicating potential benefits with some side effects.

research Shampoo Formulation

7 citations , January 2007 in “Elsevier eBooks”

This article reviews the composition and functionality of shampoos, emphasizing the role of surfactants in cleaning and conditioning hair, and reports no new experimental results.

Tolerability of Hair Cleansing Conditioners: A Double-Blind Randomized Controlled Trial Evaluating Consumer Complaints to the U.S. Food and Drug Administration

research Tolerability of hair cleansing conditioners: a double-blind randomized, controlled trial designed to evaluate consumer complaints to the U.S. Food and Drug Administration

4 citations , March 2020 in “Cutaneous and ocular toxicology”

In this double-blind, randomized controlled study, researchers found that Wen by Chaz Dean Sweet Almond Mint Cleansing Conditioner was similarly tolerated compared to three other hair cleansing conditioners and was significantly better tolerated than salicylic acid shampoo or baby shampoo in terms of skin reactions.

research Healthy Skin for Women: A Review of Common Conditions and Therapies

4 citations , March 2002 in “Journal of the American Pharmaceutical Association”

This review discusses various skin conditions affecting women throughout their lives and highlights the pharmacist's role in advising on management and treatment, but it reports no new clinical results.

research Simultaneous determination of multi-class active pharmaceutical ingredients by UHPLC-HRMS

2 citations , May 2021 in “Journal of pharmaceutical and biomedical analysis”

This study utilized a UHPLC-HRMS method to identify eight active pharmaceutical ingredients, such as ketoconazole and minoxidil, in 26 out of 100 analyzed cosmetic products.

Hyperpigmentation Associated with the Use of Topical Cidofovir for Treatment of Trichodysplasia Spinulosa in an Immunosuppressed Adult: Case Report and Review of the Literature

research Hyperpigmentation Associated with the Use of Topical Cidofovir for Treatment of Trichodysplasia Spinulosa in an Immunosuppressed Adult: Case Report and Review of the Literature

2 citations , March 2020 in “Skin”

This report highlights hyperpigmentation as an underreported side effect of topical cidofovir treatment for trichodysplasia spinulosa.

research Study of the composition of 140 shampoos: similarities and differences depending on the sales channel used

2 citations , March 2019 in “European Journal of Dermatology”

This study concluded that shampoos sold in pharmacies generally contain fewer regulated allergens under EU law compared to those sold in mass-market stores or by mail order, and pharmacy-sold baby shampoos were allergen-free.

research Hair Care Cosmetics Regulation in Different Countries – A Comparative Study

2 citations , January 2019 in “Applied clinical research, clinical trials and regulatory affairs”

This review discusses the regulations and clinical safety aspects of hair care cosmetics, highlighting the FDA's recommendation to evaluate these products for allergic reactions, avoid contamination, and include antimicrobial agents to ensure consumer safety, with ongoing monitoring through consumer feedback.

research Shampoo, conditioner and hair washing

1 citations , December 2021 in “International journal of research in dermatology”

This review discusses the evolution of modern shampoos from basic cleansing agents to products with specific therapeutic uses and emphasizes the importance of dermatologists understanding shampoo mechanisms and appropriate selection for scalp and hair health.