research Cutaneous Manifestations of Dabrafenib: A Selective Inhibitor of Mutant BRAF in Patients with Metastatic Melanoma
Dabrafenib can cause skin growths and sometimes low-grade skin cancer.
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research Tumor Regression Predicts Higher Risk of Sentinel Node Involvement in Thin Cutaneous Melanomas
Shrinking skin cancer increases the chance of cancer in nearby lymph nodes.
research Hair and Nail Adverse Events During Treatment with Targeted Therapies for Metastatic Melanoma
Targeted therapies for advanced skin cancer often cause hair and nail problems, which need managing to avoid changing the treatment dose.
research De Novo Mutation in the Mitochondrial tRNA Leu(UUR) Gene (A3243G) with Rapid Segregation Resulting in MELAS in the Offspring
A new mutation in the mitochondrial DNA was found in a boy with MELAS, even though his family didn't show typical signs.
research Whole Blood Transcriptome Profiling Identifies Candidate Genes Associated With Alopecia in Male Giant Pandas
Researchers found genes linked to hair loss in male giant pandas.
research B-RAF, Nevi and Melanoma: A Complex Relationship
Male hair loss is mainly due to thinner hair, not less hair.
research In-Vitro Effect of Sex Steroids on Mouse Melanoma (B16F10) Cell Growth
Sex steroids, especially progesterone, can slow down the growth of mouse melanoma cells.
research Fibroblast Heterogeneity and Functions: Insights from Single-Cell Sequencing in Wound Healing, Breast Cancer, Ovarian Cancer, and Melanoma
Different types of fibroblasts play specific roles in wound healing and cancer, which could help improve treatments.
research Multicentric Parallel Phase II Trial of the Polo-Like Kinase 1 Inhibitor BI 2536 in Patients With Advanced Head and Neck Cancer, Breast Cancer, Ovarian Cancer, Soft Tissue Sarcoma, and Melanoma. The First Protocol of the European Organization for Research and Treatment of Cancer Network of Core Institutes
BI 2536 had limited effectiveness against several advanced cancers and caused significant side effects.
research Determining the Relationship Among Cattle Genotype, Hair Coat Score, and Productivity Through the Investigation of Single Nucleotide Polymorphisms Within Prolactin, Dopamine Receptor D2, and Melatonin Receptor 1A
research On the Etiology of Vitiligo and Gray Hair
Melanocytes are destroyed by factors needed for melanin production, causing vitiligo and gray hair.
research Hair Cycle and Hair Pigmentation: Dynamic Interactions and Changes Associated with Aging
As people age, their hair follicles produce less pigment, leading to gray and white hair, due to factors like reduced enzyme activity and damage to melanocyte DNA.
research Hair Growth Cycle Affects Hair Follicle Destruction by Ruby Laser Pulses
Ruby laser pulses best destroy hair follicles during the growth phase and effectiveness varies with laser intensity; melanin is key for targeting, and timing treatments can improve results.
research Epidemiology of Skin Cancer in the Mature Patient
Older adults have a high rate of skin cancers like basal cell carcinoma and melanoma, mainly due to UV exposure and age.
research Poliosis Circumscripta: Overview And Underlying Causes
Poliosis circumscripta is a patch of white hair caused by lack of melanin, linked to genetic and acquired conditions.
research Curly Wood and Tiger Tails: The Tiger Tail Phenomenon in Trichothiodystrophy
Tiger tail bands in hair are caused by wavy hair fibers with melanin, unlike straight fibers in normal hair.
research Therapeutic Potential of Patient iPSC-Derived Melanocytes in Autologous Transplantation
Patient-derived melanocytes can potentially treat vitiligo by restoring skin pigmentation.
research Photochemical Alterations in Human Hair: Artificial Irradiation and Investigations of Hair Proteins
Melanin in black hair protects it from sun damage better than light-brown hair.
research Three Streams for the Mechanism of Hair Graying
Hair graying may be caused by stem cell depletion from stress or melanocyte damage.
research Dyeing Regions of Oxidative Hair Dyes in Human Hair Investigated by Nanoscale Secondary Ion Mass Spectrometry
Hair dye colors mainly target melanin granules in black hair.
research Hypopigmentation in Frontal Fibrosing Alopecia
FFA patients have fewer melanocytes and thinner skin compared to others.
research Hoxc13/β-Catenin Correlation with Hair Follicle Activity in Cashmere Goat
Hoxc13 is linked to seasonal hair growth in Cashmere goats and is affected by melatonin.
research Human Skin Color: Origin, Variation, and Significance
Human skin and hair color variation is mainly due to melanin produced by a few genes, with melanin protecting against sun damage.
research Human Hair as a Natural Sun Protection Agent: A Quantitative Study
Hair acts as a significant natural sun barrier, with protection increasing based on hair density, thickness, and melanin presence.
research Hair Pigmentation: A Research Update
Hair color is determined by different melanins and changes with age.
research 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes
A substance called TCQA could potentially darken hair by activating certain genes and increasing melanin.
research Efficacy of an Agonist of α-MSH, the Palmitoyl Tetrapeptide-20, in Hair Pigmentation
Palmitoyl tetrapeptide-20 may help reduce hair greying and increase melanin production.
research Using Morphological Operators and Inpainting for Hair Removal in Dermoscopic Images
The new algorithm removes hair from skin images better than previous methods, helping diagnose melanoma.
research Qualitative Investigation of Fresh Human Scalp Hair with Full-Field Optical Coherence Tomography
Melanin density affects hair color, and this method can help in cosmetic assessments and diagnosing hair diseases.
research Heme Oxygenase and the Skin in Health and Disease
HO-1 helps skin health and healing but can worsen melanoma; it's a potential treatment target for skin diseases.