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Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.

Male and female skin differ due to hormones, affecting conditions like hair loss, acne, and skin cancer, and suggesting a need for gender-specific treatments.

Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.

TGF-β signaling is crucial for stem cell maintenance, differentiation, and has implications for cancer treatment.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

Smoking harms the skin, causing early aging and increasing cancer risk, but stopping smoking can improve skin health.

Melanocytes are crucial for skin pigmentation and can affect conditions like melanoma, vitiligo, and albinism, as well as hair color and hearing.

Targeted cancer therapies often cause skin reactions, so dermatologists must manage these effects.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

Human skin cells produce proenkephalin, which changes with environmental factors and skin diseases.

Skin problems can be caused or worsened by physical forces and pressure on the skin.

Cancer development is like natural selection, involving mutated cells and environmental factors.

Epidermal stem cells could lead to new treatments for skin and hair disorders.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Nanotechnology in dermatology shows promise for better drug delivery and treatment effectiveness but requires more safety research.

Multiphoton microscopy is a promising tool for detailed skin imaging and could improve patient care if its challenges are addressed.

Dermatologists are more accurate than general practitioners in diagnosing skin conditions, especially skin cancer.

Finasteride increases hair density in female androgenetic alopecia, but individual results may vary.

The skin's ability to produce hormones is linked to various skin conditions, and better understanding this process could lead to new treatments.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Melanocyte precursors in human fetal skin follow a specific migration pattern and some remain in the skin's deeper layers.

Targeted cancer therapies often cause skin problems that need careful management to improve patient quality of life and treatment success.

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

The hair follicle infundibulum plays a key role in skin health and disease, and understanding it better could lead to new skin disease treatments.

Pregnancy can change skin disease severity, with some conditions improving and others worsening, and treatment should balance benefits and fetal safety.

MicroRNAs are important for skin health and could be targets for new skin disorder treatments.

Certain microRNAs are linked to various skin diseases and could be used to diagnose and treat these conditions.

The review found that different stem cell types in the skin are crucial for repair and could help treat skin diseases and cancer.

Taking too many vitamin and mineral supplements can cause serious health problems.

The document concludes that veterinary dermatologists need more experience and a better approach to treating skin diseases in nonhuman primates.