Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This case report describes a dog diagnosed with discoid lupus erythematosus, presenting unusually with perianal rather than facial lesions, which resolved after corticosteroid treatment.

This study details the characteristics of lipedematous alopecia and lipedematous scalp, two rare scalp conditions, suggesting they may represent different stages of the same disorder, with lipedematous scalp lacking the hair loss seen in lipedematous alopecia.

In this study, gene expression analysis of plucked hair follicles from scalp lesions was sufficient to differentiate chronic discoid lupus erythematosus from psoriasis and healthy controls, suggesting a non-invasive diagnostic potential.

This study presents a case of neuropsychiatric lupus in a 50-year-old woman, highlighting the severe impact on quality of life and the necessity for aggressive treatment to improve outcomes.

In this study, NKG2D polymorphism was not linked to increased susceptibility to systemic lupus erythematosus among Egyptian patients living in the Suez Canal area.

In this case report, a rare instance of Graham–Little–Piccardi–Lassueur syndrome coexisting with linear lichen planus was identified in a 35-year-old male, highlighting the condition's rarity in males, with dermoscopy aiding diagnosis through distinctive scalp and trunk lesion features.

This case report highlights the importance of trans-esophageal echocardiography in distinguishing Libman-Sacks endocarditis from infective endocarditis in systemic lupus erythematosus patients, guiding appropriate treatment for associated cerebrovascular disease.

This study reports that the symptoms and immunological findings in two children with diverse autoimmune-like conditions were ultimately attributed to lysinuric protein intolerance, confirmed by genetic analysis in one child.

Scarring alopecia involves increased immune cells and specific gene changes near damaged hair follicles.

In this research, RNA expression analysis of scalp biopsies from lichen planopilaris patients revealed changes in specific genes after treatments with hydroxychloroquine, narrow band UVB, or low level laser light therapy, suggesting potential biomarkers and implicating M2 macrophages in the disease's immunopathogenesis.

The authors concluded that low energy laser therapy may serve as a useful complementary treatment for skin diseases such as lichen planus, infectious finger pulpits, scalp alopecia, and crural ulcers.

This review identifies genetic mutations associated with congenital hair loss disorders in Japanese populations, particularly highlighting common LIPH gene mutations linked to woolly hair/hypotrichosis, and reports no new clinical results.

This review discusses the pathophysiologic role of lysophosphatidic acid in the skin and reports no clinical results, suggesting pharmacological inhibition as a potential treatment for various skin disorders.

This case report presents a young woman with systemic lupus erythematosus who was found to have CD4+ lymphocytopenia.

This thesis found that in lupus nephritis, traditional classification criteria may not apply to patients with glomerular deposits without clinical SLE, indicating distinct prognostic and diagnostic challenges.

This review discusses the role of RDH12 in vision, its structural and functional aspects, and related disease mechanisms, but reports no new clinical results; it aims to support therapy development for inherited retinal dystrophies.

RNase L suppresses regeneration in mammals.

This study discovered a novel interaction between the vitamin D receptor and LEF1, essential for normal Wnt signaling in keratinocytes, which is crucial for regular hair cycling.

This case report describes a 46,XY female patient with a novel homozygous nonsense mutation in the LHCGR gene, highlighting the need for molecular analysis in disorders of sexual development.

Treat limited stage small cell lung cancer with chemotherapy and radiation, and consider preventive brain radiation for better survival chances.

This study found that BBS7 is crucial for maintaining Sonic hedgehog signaling activity and periodontal ligament homeostasis, with changes in gene expression observed in occlusal hypofunctional PDL.

This study explored a mother and daughter with loose anagen hair syndrome linked to wooly hair, identifying an intronic variant in the KRT71 gene that affects hair keratin splicing, thus broadening the spectrum of KRT71-related disorders.

This study found that a keratin mutation may cause diffuse partial woolly hair associated with loose anagen hair syndrome in some families, but other genetic factors could play a role in different cases.

In this study, researchers found that the SLICK1 allele in cattle may alter local immune regulation, hair growth, and tissue remodeling, as indicated by differential gene expression pathways associated with immune and inflammatory responses in slick vs. nonslick Holsteins.

This study identified Lgr5 and Lgr6 as receptors expressed by small populations of stem cells in various adult organs, with Lgr5+ve cells forming long-lived organoids in certain mouse models.

This review discusses the applications of low level laser therapy (LLLT) in wound healing, pain reduction, and treating various conditions, but reports no new clinical results; the authors highlight the need for randomized controlled trials for serious diseases.

This study found that impaired TCF/Lef1 signaling in mice leads to significant skin barrier defects due to altered lipid metabolism and epidermal differentiation.

This report presented a case of a patient with basal cell carcinoma and systemic lupus erythematosus who was treated successfully with sonidegib, showing positive outcomes without worsening lupus activity, despite lacking documented clinical use of sonidegib in such patients.

This review discusses various applications of low level laser therapy and argues for a holistic evaluation of patients but reports no new clinical findings.

In this mouse model study, researchers found that deleting the ASH2L gene in epidermal progenitor cells led to thinner epidermal layers, delayed hair follicle development, and reduced epidermal stem cell pools, with alterations in genes related to hair follicle development and the Notch signaling pathway.