Plucked Hair Follicles From Patients With Chronic Discoid Lupus Erythematosus Show a Disease-Specific Molecular Signature

    July 2019 in “ Lupus Science & Medicine ”
    Mohammad Shalbaf, Adewonuola Alase, Anna Berekméri, Md Yuzaiful Md Yusof, Jelena Pistolic, Mark Goodfield, Sara Edward, Natalia V. Botchkareva, Martin Stacey, Edward M Vital, Miriam Wittmann
    TLDR Plucked hair follicles can help diagnose scalp lupus.
    The study investigated a non-invasive diagnostic method for chronic discoid lupus erythematosus (CDLE) by analyzing plucked hair follicles (HFs) from 7 CDLE patients, 6 psoriasis patients, and 5 healthy controls. It identified a disease-specific molecular signature in CDLE, characterized by upregulation of interferon-stimulated genes, complement components, and genes related to apoptosis and CD8+ T-cell responses. These findings suggested that CDLE causes irreversible alopecia due to immune-mediated damage to the HF stem cell niche. The research indicated that plucked HFs could potentially replace invasive scalp biopsies for diagnosing CDLE, though further clinical validation was needed.
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