Systemic Lupus Erythematosus: From Diagnosis to Prognosis

    October 2017 in “ Data Archiving and Networked Services (DANS) ”
    Emilie C. Rijnink
    TLDR Current SLE classifications need refinement, and the complement system is a key therapeutic target.
    The thesis explored the diagnosis and prognosis of systemic lupus erythematosus (SLE), particularly focusing on lupus nephritis (LN) and neuropsychiatric SLE (NP-SLE). It was found that classification criteria for SLE were not always applicable to nephrology patients with full house glomerular deposits, who often had poor renal outcomes despite not having clinical SLE. Additionally, the study identified clinical and histopathologic factors that could help predict renal outcomes in LN, highlighting a subgroup of patients with class III/IV LN who had favorable renal outcomes. This research aimed to improve the understanding and prognostication of SLE-related conditions.
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