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Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride

research Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride

25 citations, September 1998 in “The Journal of Steroid Biochemistry and Molecular Biology”

Finasteride inhibits enzyme activity in rhesus macaques, suggesting they're useful for evaluating similar drugs.

Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Visceral and Subcutaneous Adipose Tissues of Patients with Polycystic Ovary Syndrome Is Associated with Adiposity

research Expression of 11β-Hydroxysteroid Dehydrogenase Type 1 in Visceral and Subcutaneous Adipose Tissues of Patients with Polycystic Ovary Syndrome Is Associated with Adiposity

18 citations, December 2010 in “The Journal of Steroid Biochemistry and Molecular Biology”

Increased HSD11B1 enzyme expression is linked to higher body fat and insulin resistance.

In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions

research In Vitro Selective Inhibition of Human UDP-Glucuronosyltransferase (UGT) 1A4 by Finasteride and Prediction of In Vivo Drug–Drug Interactions

13 citations, January 2015 in “Toxicology Letters”

Finasteride affects UGT1A4 enzyme, but not enough to cause issues when combined with other drugs.

Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates

research Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates

13 citations, August 1995 in “The Journal of Steroid Biochemistry and Molecular Biology”

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

research Structure-Guided Manipulation of the Regioselectivity of the Cyclosporine A Hydroxylase CYP-sb21 from Sebekia Benihana

3 citations, July 2020 in “Synthetic and Systems Biotechnology”

Scientists improved an enzyme to better produce a hair growth-promoting chemical from an immunosuppressant.

research The Rotterdam Study: 2012 Objectives and Design Update

247 citations, August 2011 in “European Journal of Epidemiology”

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

research Targeting the Pre-Receptor Metabolism of Cortisol as a Novel Therapy in Obesity and Diabetes

70 citations, March 2010 in “The Journal of Steroid Biochemistry and Molecular Biology”

Blocking a specific enzyme might help treat obesity and diabetes, but more research is needed to ensure it's safe.

research Food Deprivation-Induced Expression of Minoxidil Sulfotransferase in the Hypothalamus Uncovered by Microarray Analysis

36 citations, March 2002 in “Journal of Biological Chemistry”

Food deprivation increases MST enzyme in the brain, possibly affecting energy balance.

research Inhibitory Effects of Serenoa Repens on the Kinetics of Pig Prostatic Microsomal 5α-Reductase Activity

12 citations, January 1998 in “Endocrine journal”

Saw palmetto extract can block the enzyme that converts testosterone in pig prostate cells.

research Integrin Beta 1 Establishes Liver Microstructure and Modulates Transforming Growth Factor Beta During Liver Development and Regeneration

10 citations, November 2020 in “American Journal Of Pathology”

Integrin β1 is crucial for liver structure and function, preventing fibrosis.

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