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Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Surgeons must understand the full care process for gender confirmation surgery to help transgender individuals effectively.

Isotretinoin effectively treats severe acne and similar conditions, but has common, mostly reversible side effects, requiring careful patient monitoring.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

Vitamin D has potential benefits for cancer prevention, heart health, diabetes, obesity, muscle function, skin health, and immune function, but clinical results are mixed and more research is needed.

Fibroblast growth factor receptor signaling controls cell development and repair, and its malfunction can cause disorders and cancer, but it also offers potential for targeted therapies.

Women with PCOS are more than twice as likely to develop nonalcoholic fatty liver disease.

Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.

All-trans retinoic acid causes hair loss by increasing TGF-β2 in hair follicle cells.

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

Pregnancy can increase lupus activity, but careful planning and treatment can improve outcomes.

Correcting nutrient deficiencies may help with hair loss, but the benefits of supplements without a deficiency are uncertain and could be harmful.

Some common medications can harm male fertility, but many effects can be reversed.

Triparanol therapy can cause hair loss and skin dryness without inflammation or damage to hair follicles or skin structures.

Most dermatologic medications are safe during pregnancy and breastfeeding, but some should be avoided due to potential risks.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

The conclusion is that published guidelines are improving transgender medical care, but more research and education in transgender medicine are needed.

Doctors need to be better prepared to assess and treat obesity in patients.

Lamins are vital for cell survival, organ development, and preventing premature aging.

Products should be called 'sperm-safe' only after thorough, well-designed tests.

Mutations in the LSS gene cause a rare type of hereditary hair loss.

Some skin conditions may indicate metabolic syndrome, which could help with early detection and management of related health issues.

The document concludes that mouse models are crucial for studying hair biology and that all mutant mice may have hair growth abnormalities that require detailed analysis to identify.

Mutations in the hairless gene in mice affect its expression and lead to a range of developmental issues in multiple tissues.

The cosmetic industry should adapt to the varied beauty standards of ethnic groups and offer specialized treatments.

Nanoparticles show promise for better wound healing, but more research is needed to ensure safety and effectiveness.

Valproic acid may help hair grow and could be a safe treatment for hair loss.

Valproic Acid could potentially be used to treat immune-related conditions due to its ability to modify immune cell functions.

Mice lacking Insig proteins had hair growth problems due to cholesterol buildup, but this was fixed by the drug simvastatin.

Genetic mutations can cause hair growth disorders by affecting key genes and signaling pathways.