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The document concludes that permanent hair loss conditions are complex, require early specific treatments, and "secondary permanent alopecias" might be a more accurate term than "secondary cicatricial alopecia."

Minoxidil effectively lowers blood pressure in patients with resistant hypertension.

Hair loss may indicate higher risk of heart disease.

MicroRNAs are crucial in controlling cell signaling, affecting cancer and tissue regeneration.

The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Turning white fat into brown-like fat could help fight obesity and type 2 diabetes.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

The bulletin provides guidelines for diagnosing and managing PCOS, suggesting weight loss, hormonal contraceptives, and diabetes screening, with clomiphene for infertility and various treatments for excess hair.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The guidelines advise against using testosterone and DHEA in women for most conditions due to safety and effectiveness concerns, but suggest considering testosterone for postmenopausal women with low sexual desire.

Insulin resistance and obesity are key factors in the development and worsening of polycystic ovary syndrome, and lifestyle changes are important for managing it.

The peptide GHK-Cu helps heal and remodel tissue, improves skin and hair health, and has potential for treating age-related inflammatory diseases.

Hair follicle stem cells are key for hair and skin regeneration, can be reprogrammed, and have potential therapeutic uses, but also carry a risk of cancer.

Minoxidil treats hair loss, promotes growth, has side effects, and has recent patents.

Low doses of some substances can be beneficial, while high doses can be harmful or toxic.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

We need more research to better understand human hair follicle stem cells for improved treatments for hair loss and skin cancer.

Formyl-peptide receptor agonists could be new anti-inflammatory drugs.

Male hormones and their receptors play a key role in hair loss and skin health, with potential new treatments being explored.

The human hair follicle can store topical compounds and be targeted for drug delivery with minimal side effects.

Hormonal treatments, including birth control and antiandrogens, can effectively treat acne in women.

Circadian rhythms are crucial for stem cell function and tissue repair, and understanding them may improve aging and regeneration treatments.

New treatments for male hypogonadism are effective and should be personalized.

Targeting the skin's endocannabinoid system could help treat skin disorders.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

Topical drugs and near-infrared light therapy show potential for treating alopecia.

Different types of facial fat affect aging and treatment outcomes; more research is needed to enhance anti-aging procedures.

Some plant-based treatments can help with benign prostatic hyperplasia symptoms, but more research is needed to confirm their safety and effectiveness.