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    Glossary Lipid Production

    cells create essential fats and oils for energy and structure

    Lipid production, also known as lipid synthesis or lipid biosynthesis, is the process by which cells create lipids, which are essential fats and oils. These lipids play crucial roles in storing energy, forming cell membranes, and serving as signaling molecules. The process involves converting simpler molecules like acetyl-CoA into complex lipids through enzymatic reactions, primarily occurring in the liver and adipose tissue.

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    1. Adiponectin Signaling Regulates Lipid Production in Human Sebocytes PLoS ONE · 2017 · 32 citations
    2. Production of mannosylerythritol lipids and their application in cosmetics Applied Microbiology and Biotechnology · 2013 · 84 citations
    3. Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis Cell Reports · 2025 · 5 citations
    4. 1321 Endocannabinoid-like molecule oleoylethanolamide promotes sebaceous lipid synthesis Journal of Investigative Dermatology · 2018 · 1 citations
    5. 0952 Spatial transcriptomics reveal compartmentalized dysregulation of lipid metabolism in acne vulgaris Journal of Investigative Dermatology · 2025
    6. Primary cilia regulate Meibomian glands development and dimensions without impairing lipid composition of the meibum bioRxiv (Cold Spring Harbor Laboratory) · 2022
    7. 1317 Nicotinic acid suppresses sebaceous lipid synthesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2) Journal of Investigative Dermatology · 2018
    8. Ozenoxacin suppresses sebum production by inhibiting mTORC1 activation in differentiated hamster sebocytes The Journal of Dermatology · 2024 · 6 citations
    9. Re: Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial The Journal of Urology · 2012
    10. Normal Fur Development and Sebum Production Depends on Fatty Acid 2-Hydroxylase Expression in Sebaceous Glands 2011 · 40 citations
    11. Sebum Production Springer eBooks · 2016 · 1 citations
    12. 1329 Transglutaminase 2 deficiency leads to lipid accumulation and reduced autophagy in SZ95 sebocytes 2023
    13. 696 MEK and BRAF inhibitors augment the production and accumulation of sebum in hamster sebocytes Journal of Investigative Dermatology · 2016
    14. ANTI-ACNE ACTIVITY OF LIPIDO-STEROLIC EXTRACT OF SERENOA REPENS AND HYDRO-ALCOHOLIC EXTRACT OF GLYCYRRHIZA GLABRA IN SYRIAN HAMSTER EAR MODEL Zenodo (CERN European Organization for Nuclear Research) · 2017
    15. Runx1 Role in Epithelial and Cancer Cell Proliferation Implicates Lipid Metabolism and Scd1 and Soat1 Activity Stem cells · 2018 · 24 citations
    16. Refatting rate of human hair lipids after exposure to selenium disulphide detergents International Journal of Cosmetic Science · 1983 · 2 citations
    17. Comprehensive analysis of differences in cashmere production performance in Liaoning cashmere goats by using metabolomics and transcriptomics Frontiers in Veterinary Science · 2025
    18. 548 Deletion of Myelin Protein Zero-like 3 increases sebaceous gland size and sebocyte proliferation but reduces skin adipose depots: Can MPZL3 inhibition promote excessive loss of lipids via sebum hypersecretion? Journal of Investigative Dermatology · 2022
    19. Effects of dietary supplementation with taurine on production performance of Angora rabbits World rabbit science · 2021
    20. Maternal PPARγ protects nursing neonates by suppressing the production of inflammatory milk Genes & Development · 2007 · 102 citations
    21. Prostaglandin D2 Uses Components of ROS Signaling to Enhance Testosterone Production in Keratinocytes Journal of Investigative Dermatology Symposium Proceedings · 2017 · 9 citations
    22. Advances in mitochondria-centered mechanism behind the roles of androgens and androgen receptor in the regulation of glucose and lipid metabolism Frontiers in endocrinology · 2023
    23. Severe Skin Permeability Barrier Dysfunction in Knockout Mice Deficient in a Fatty Acid ω-Hydroxylase Crucial to Acylceramide Production Journal of Investigative Dermatology · 2019 · 40 citations
    24. Androgens Affect the Activity of Human Sebocytes in Culture in a Manner Dependent on the Localization of the Sebaceous Glands and Their Effect Is Antagonized by Spironolactone Skin Pharmacology and Physiology · 1994 · 40 citations
    25. Comparative studies of the ultrastructure of the sebaceous gland Tissue and Cell · 1985 · 40 citations
    26. Genetically modified laboratory mice with sebaceous glands abnormalities Cellular and Molecular Life Sciences · 2016 · 22 citations
    27. PLCD1 and Pilar Cysts 2019 · 5 citations
    28. Topical Spironolactone in the Treatment of Ocular Graft-Versus-Host Disease Curēus · 2023 · 2 citations
    29. Efficacy of 0.1% adapalene in a non-inflammatory Kyoto Rhino Rat acne model Journal of dermatological science · 2014 · 2 citations
    30. Single-cell analysis of 2,3,7,8-tetrachlorodibenzo- <i>p</i> -dioxin (TCDD)-treated murine skin demonstrates that sebaceous gland differentiation precedes <i>Ahr</i> -dependent seboatrophy with elevated expression of infundibular <i>Blimp1</i> bioRxiv (Cold Spring Harbor Laboratory) · 2026