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The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.

The Rotterdam Study aims to understand various diseases in older adults.

Chemotherapy causes hair loss by damaging hair follicles and stem cells, with more research needed for prevention and treatment.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

The document concludes that recognizing and treating cutaneous lupus erythematosus early is crucial for managing the skin and potential systemic symptoms.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Men generally have more severe COVID-19 cases and higher death rates than women due to biological differences.

Understanding how cells die in the skin is important for treating skin diseases and preventing hair loss.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

Certain mice without specific receptors or mast cells don't lose hair from stress.

Some heart drugs show promise for other conditions, but more research is needed to confirm their effectiveness and safety.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Some psychiatric medications can cause hair loss, but it usually grows back after adjusting the medication.

Using minoxidil on dogs can cause serious cardiovascular damage, including arterial injury and hemorrhagic lesions.

Testosterone may slow down wound healing and increase inflammation.

Blocking Wnt signaling in young mice causes thymus shrinkage and cell loss, but recovery is possible when the block is removed.

The document concludes with guidance for doctors on diagnosing and treating hirsutism effectively and safely.

The document concludes that more research is needed to understand how to treat muscle pain with drugs.

Nanoparticles show promise for better wound healing, but more research is needed to ensure safety and effectiveness.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

Hormone imbalances can cause specific skin changes, which may help in early detection of endocrine disorders.

Androgen Deprivation Therapy for prostate cancer often reduces sexual function but intermittent therapy may be more tolerable.

Hormone treatments can help with women's skin and hair disorders, but they need careful monitoring and more research.