January 1994 in “Nippon Ronen Igakkai Zasshi Japanese Journal of Geriatrics” In this study, both VEPA and ML-Y1 treatment regimens for older patients with non-Hodgkin's lymphoma showed similar response and survival rates, but neither was sufficient, indicating the need for a more effective approach.
1 citations
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September 2024 in “Journal of Oncology Pharmacy Practice” In this report, a 77-year-old woman treated for essential thrombocytosis with low-dose hydroxyurea experienced an unexpected change in hair color from gray to dark brown after 20 weeks, highlighting a potential aesthetic side effect of the drug, in addition to therapeutic effects.
76 citations
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May 2011 in “Liver transplantation” The authors concluded that liver transplantation in children with propionic acidemia can reduce the risk of metabolic decompensation and enhance quality of life, although some metabolic issues may persist.
December 2022 in “Acta Ophthalmologica” In this study, dutasteride treatment in retinitis pigmentosa mice increased photoreceptor survival and reduced glial activation, suggesting it may offer a neuroprotective effect.
March 2026 in “FEBS Open Bio” This study found that 5-aminolevulinic acid combined with ferric ammonium citrate stimulated hair follicle growth and induced hair-like structures in human hair follicle models, suggesting its potential as a treatment for hair loss.
June 2021 in “Clinical neuropsychopharmacology and therapeutics” This paper reviews the hair color changes associated with valproic acid treatment, noting only a few reported instances of bleaching or darkening, and reports no new findings.
14 citations
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November 2016 in “Lupus” In this retrospective study of adolescents with recalcitrant cutaneous lupus, lenalidomide treatment resulted in complete or near resolution of skin symptoms within 6 months, while allowing for a reduction in prednisone dosage.
This study found that men with early-onset androgenic alopecia may be partially resistant to the cardiometabolic benefits of bromocriptine compared to those with normal hair growth.
52 citations
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July 1998 in “Urology” This study found that liarozole is more effective than cyproterone acetate for improving PSA response and survival in metastatic prostate cancer after first-line endocrine therapy, while maintaining quality of life.
23 citations
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June 1950 in “American journal of diseases of children” This article discusses the interest in folic acid antagonists for leukemia treatment, noting their potential mechanism of interfering with cellular growth, but reports no new clinical results.
January 1994 in “Toxicological Sciences” This study found that chronic high dosages of 2-(difluoromethyl)-dl-ornithine caused various toxicities in rats and dogs, with some effects potentially minimized at lower dosages.
December 2024 in “International Journal of Drug Delivery Technology” This study reports that a novel Nano-Structured Lipid Carrier system for delivering dutasteride may enhance its anticancer effects while reducing systemic side effects in clinical settings.
July 2004 in “Journal of Clinical Oncology” This study found that therapeutic isolated limb perfusion with melphalan for in-transit melanoma metastases resulted in a high response rate but was associated with some systemic toxicity, including nausea, vomiting, and transient bone marrow depression.
16 citations
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January 2001 in “Clinical and Experimental Dermatology” Photodynamic therapy was effective in treating multiple scalp basal cell carcinomas with minimal side effects and good cosmetic results.
3 citations
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September 1980 in “Experientia” In this study, the pharmacological action of dobutamine on rabbit retinae was found to be distinct from that of other dopamine analogs like apomorphine and N-methyl-dopamine.
4 citations
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January 1982 in “Neuroendocrinology” This study found that pimozide, d-butaclamol, and pituitary pars intermedia grafts darken hair color in agouti C3H Avy mice, suggesting dopaminergic inhibition influences peptide-controlled hair color cycling.
53 citations
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October 2011 in “Psychoneuroendocrinology” Finasteride may help improve certain brain function issues linked to dopamine.
45 citations
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July 2002 in “The Neurologist” This article reviews the challenges of using disease-modifying therapy for multiple sclerosis and offers strategies to improve treatment adherence and manage adverse effects, but reports no new clinical findings.
14 citations
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December 2017 in “Journal of Intensive Care” Lithium poisoning can cause severe health complications and requires careful monitoring.
22 citations
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November 2002 in “Clinical journal of oncology nursing” This article discusses arsenic trioxide as a treatment for refractory or relapsed acute promyelocytic leukemia, noting its effectiveness and manageable side effects.
4 citations
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September 2025 in “Journal of the American Academy of Dermatology” The trial helped find the best dose of deuruxolitinib for treating alopecia areata.
January 2018 in “Practical diabetes” In this study, leflunomide was effective in treating rheumatoid arthritis, showing comparable efficacy to methotrexate and greater response rates than sulfasalazine, but has significant side effects that require monitoring.
14 citations
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April 2005 in “Experimental Dermatology” This study found that stressed dermal fibroblasts significantly increased dopa oxidase activity in melanocytes from hair, skin, and eyes, suggesting the involvement of fibroblast-derived factors like basic Fibroblast Growth Factor.
April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that in a mouse model of Focal Dermal Hypoplasia, treatment with lithium carbonate improved skin disease symptoms compared to controls, though disease severity varied and posed interpretation challenges.
17 citations
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February 2001 in “Journal of the American Academy of Dermatology” This case report suggests that lithium, either alone or with haloperidol, may induce skin changes resembling follicular mycosis fungoides.
15 citations
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July 2022 in “Nano Research” This study suggests that using cholesterol-free liposomes, specifically PPD-Lip, as a delivery system with dutasteride may enhance the treatment of androgenetic alopecia by promoting hair regrowth in mice models.
April 2025 in “Journal of Oncology Pharmacy Practice” This study found that a lotion containing an alpha lipoic acid derivative increased hair diameter in chemotherapy patients with gastric or colorectal cancer, while those not using the lotion had more pronounced hair loss, suggesting potential benefits in managing chemotherapy-induced alopecia.
This systematic review reported that treatment with drugs that activate the Wnt pathway, including valproic acid and lithium, was not associated with a significant increase in cancer risk. The authors suggest further research on Wnt activation's potential as a regenerative therapy.
1 citations
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November 2025 in “International Journal of Clinical Pharmacy” This study confirms known risks of cladribine and reveals potential new safety concerns, emphasizing the need for careful monitoring for early acute toxicity.
6 citations
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February 2009 in “Journal of Investigative Dermatology”