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This study found that feeding sheep rations with up to 30% Leucaena leucocephala leaf meal did not significantly affect mimosine concentrations or alter blood metabolites and thyroid hormones, suggesting it can be used without detrimental effects in these aspects.

This study established a simple and accurate LC-MS method for quantifying vinflunine in Beagle dog plasma, supporting pharmacokinetic research in this context.

In this study, higher doses of daunorubicin during induction therapy significantly improved complete remission rates in young adults with acute myeloid leukemia.

In a rodent study, researchers found that oral phenytoin and spironolactone significantly mitigated 5-fluorouracil-induced hair loss and oxidative stress, suggesting potential therapeutic benefits for chemotherapy-induced alopecia and enhanced recovery.

In this study, acute liver disease occurred in five patients, including four children, after treatment with sodium valproate, leading to the death of three patients.

Mitoxantrone is effective for treating acute leukemia, especially in older patients, with a lower risk of heart damage.

This study found that FOLFOX6 chemotherapy significantly decreased serum VEGF and CRP levels in advanced colorectal cancer patients, improved their quality of life as measured by KPS scores, and demonstrated a high overall therapeutic efficacy of 82.72% with manageable side effects.

This study found that thrombocytopenia is a common side effect of valproic acid, affecting up to 54% of elderly patients, but it is under-investigated despite significant therapeutic consequences.

This article discusses leukocytoclastic vasculitis, particularly its triggers, manifestations, and treatments, and reports no new experimental results; the authors highlight valproic acid's association with this condition.

This study found that vinblastine treatment rapidly increased platelet counts in childhood refractory immune thrombocytopenia, providing effective control of bleeding symptoms, although side effects like neuropathic pain were common and resolved with dose adjustments.

In this study, sustained-release sodium valproate showed high efficacy in achieving seizure remission for adults with focal and generalized epilepsy over one year, but side effects like weight gain and tremor were more frequent among heterozygous carriers of certain gene variants.

This study found that holding abatacept infusions for four weeks or longer before elective hip or knee arthroplasty did not reduce the risk of post-operative infections or readmissions.

This case report describes proguanil-related hematologic toxicity in a patient on peritoneal dialysis, suggesting that this malaria prophylaxis should be avoided in chronic kidney disease due to proguanil accumulation.

This article discusses the potential of intralesional cidofovir as a treatment for SCC and reports no systemic toxicity, but highlights surgical excision as the most reliable curative option.

In this study, vitiligo patients treated with a combination of fractional CO2 laser or microneedling followed by topical 5-Fluorouracil experienced more effective and safe outcomes compared to using either method alone.

This study tested a folate-conjugate drug delivery system and found its cytotoxicity depends on whether the treated cells overexpress folate receptors, suggesting potential for targeted chemotherapy.

This case report describes a rare instance of successful treatment of feline leishmaniosis in a cat, with noted nephrotoxic effects possibly linked to long-term allopurinol use.

The trial helped find the best dose of deuruxolitinib for treating alopecia areata.

This study at Al-Azhar University Hospitals found that combining a fractional CO2 laser or microneedling with topical 5-Fluorouracil (5-FU) is more effective and safe for treating vitiligo than using either treatment alone, offering a new therapeutic option for patients.

This article reviews potential drug and herbal interactions with warfarin that may increase bleeding risk, and reports no new clinical results.

This case study describes a 59-year-old man with scurvy, initially misdiagnosed as leukocytoclastic vasculitis, who showed rapid improvement after vitamin C supplementation; it reviews scurvy's biochemical basis, symptoms, and management.

This study found that both levetiracetam and valproate sodium effectively reduced seizure frequency and duration in patients with refractory epilepsy, but levetiracetam had fewer side effects related to liver enzyme changes.

This review discusses the potential of combined therapy with WP 631 and epothilone B for ovarian cancer, but reports no new clinical results.

In this study, the researchers developed a deep learning framework to pre-emptively screen for adverse drug effects, showing strong predictive performance, including for increased bleeding risks with edoxaban compared to other anticoagulants.

This review update suggests that mycophenolate mofetil may increase complete disease remission in proliferative lupus nephritis compared to intravenous cyclophosphamide, but with low certainty of evidence.

This review compiles recent findings on the pharmacokinetics, pharmacodynamics, and pharmacogenomics of Valproate, highlighting potential new uses, benefits, and risks, but reports no new clinical results.

Adjusting the medication tacrolimus resolved a boy's red nail beds after a stem cell transplant.

This source describes vitiligo as a chronic condition marked by the loss of skin pigmentation and discusses leukotrichia, a feature affecting 10% to 60% of cases, which arises from melanocyte loss in hair follicles and appears as well-defined white patches on the skin.

This study found that mycophenolate mofetil was associated with higher response rates and lower rates of serious side effects, including a lower mortality rate, compared to cyclophosphamide in lupus nephritis treatment.

In this study, Convulsofin was effective as monotherapy for generalized primary epilepsy and as adjunctive treatment for therapy-resistant secondary and partial epilepsy, though side effects like gastrointestinal issues and weight gain were noted.