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Most drugs fail to reach the market, but understanding their properties and using strategies like early toxicity tests and drug repurposing can help advance their development.

Recent selection on immune response genes was identified across seven ethnicities.

Women with PCOS face many health risks, but exercise, a healthy diet, and weight management can help.

Higher TGF-β signaling may increase skin cancer risk in organ transplant recipients.

Homeopathic remedies can help manage PCOS symptoms in girls aged 17-21.

Cyclophosphamide helped 59.4% of children with steroid-resistant nephrotic syndrome but caused side effects in 40.6%.

Keratin-associated proteins have ancient origins and were used for different purposes before being adapted for hair in mammals.

The Li-Pa/Ca and Do/Ca chemotherapy regimens for serous ovarian cancer showed better short-term and long-term results than the Pa/Ca regimen.

Protein hair straighteners damage the hair more than hair dyes.

A patient with myotonic dystrophy had several autoimmune disorders and thyroid cancer, suggesting a possible link between these conditions.

Exosomes show promise for tissue repair and regeneration with advantages over traditional cell therapies.

Using lidocaine before keloid injections makes the treatment more comfortable for patients.

The document tests knowledge and decision-making in hematology through multiple-choice questions.

The document provides 70 multiple choice questions to improve haematology skills.

Spironolactone can cause side effects like high potassium levels and breast enlargement, and patients need careful monitoring.

Men who start losing hair at 20 may have a higher chance of getting prostate cancer later.

A woman's adrenal tumor disappeared after treatment with cyproterone acetate.

The symposium concluded that hair growth involves complex processes, including the hair follicle life cycle, the role of the dermal papilla, hair strength, pigmentation, and the impact of diseases and treatments like minoxidil on hair and skin.

Chemotherapy in the first trimester of pregnancy is risky, but in the second and third trimesters, it's generally safe with careful drug selection and timing.

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

A mother's diet at conception can cause lasting genetic changes in her child.

Improving artificial vascular grafts requires better materials and surface designs to reduce blood clotting and support blood vessel cell growth.

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

β-catenin is essential for stem cell activation and proliferation in hair follicles.

Cushing's syndrome can cause serious health problems, and early treatment is crucial, but some issues may remain after treatment.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

The Rotterdam Study found risk factors for elderly diseases, links between lifestyle and genetics with health conditions, and aimed to explore new areas like DNA methylation and sensory input effects on brain function.