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    Glossary Janus Kinase Inhibitors

    medications that block enzymes involved in immune response signaling

    Janus Kinase Inhibitors, often referred to as JAK inhibitors, are a class of medications that block the activity of Janus kinases, which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage conditions like rheumatoid arthritis, psoriasis, and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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    1. A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral Janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results Journal of the American Academy of Dermatology · 2021 · 138 citations
    2. Janus kinase inhibitors in dermatology: A systematic review Journal of the American Academy of Dermatology · 2017 · 116 citations
    3. The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases 2020 · 70 citations
    4. Janus Kinase Inhibitors for the Treatment of Severe Alopecia Areata: An Open-Label Comparative Study Dermatology · 2018 · 66 citations
    5. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    6. Role of janus kinase inhibitors in the treatment of alopecia areata Drug design, development and therapy · 2018 · 53 citations
    7. Janus kinase (JAK) inhibitors for the treatment of skin and hair disorders: a review of literature Journal of Dermatological Treatment · 2016 · 40 citations
    8. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    9. Comparative efficacy of oral Janus kinase inhibitors and biologics in adult alopecia areata: A systematic review and Bayesian network meta‐analysis Journal of the European Academy of Dermatology and Venereology · 2024 · 20 citations
    10. The role of Janus kinase inhibitors in the treatment of alopecia areata: A systematic review Dermatologic therapy · 2019 · 19 citations
    11. The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature Journal of cutaneous medicine and surgery · 2019 · 17 citations
    12. Janus Kinase Inhibitors in Dermatology: Part 1 — General Considerations and Applications in Vitiligo and Alopecia Areata Actas Dermo-Sifiliográficas · 2021 · 14 citations
    13. Unexpected Hair Regrowth in a Patient with Longstanding Alopecia Universalis During Treatment of Recalcitrant Dermatomyositis with the Janus Kinase Inhibitor Ruxolitinib Acta Dermato Venereologica · 2020 · 13 citations
    14. Janus Kinase Inhibitors for Alopecia Areata JAMA network open · 2023 · 12 citations
    15. Systematic review of newer agents for the management of alopecia areata in adults: Janus kinase inhibitors, biologics and phosphodiesterase‐4 inhibitors 2022 · 12 citations
    16. Janus kinase inhibitors: An innovative treatment for alopecia areata Journal of dermatology · 2019 · 11 citations
    17. Translational Positioning of Janus Kinase (JAK) Inhibitors in Alopecia Areata EBioMedicine · 2015 · 11 citations
    18. Comparative Efficacy and Safety of Janus Kinase Inhibitors Used in Alopecia Areata: A Systematic Review and Meta-analysis Acta dermato-venereologica · 2023 · 10 citations
    19. Various Applications of Tofacitinib and Ruxolitinib (Janus Kinase Inhibitors) in Dermatology and Rheumatology: A Review of Current Evidence and Future Perspective Dermatology practical & conceptual · 2022 · 8 citations
    20. Janus kinase inhibitors for alopecia areata Journal of the American Academy of Dermatology · 2023 · 7 citations
    21. Janus Kinase Inhibitors against Other Biological Treatments in Alopecia Areata Scandinavian journal of immunology · 2016 · 6 citations
    22. 544 Alopecia areata lesions show significant changes in immune and keratin biomarkers that correlate with clinical improvement with oral Janus kinase inhibitors PF-06651600 (JAK3) and PF-06700841 (TYK2/JAK1) Journal of Investigative Dermatology · 2019 · 5 citations
    23. Janus kinase inhibitors for alopecia areata: a review of clinical data Frontiers in Immunology · 2025 · 4 citations
    24. A review of Janus kinase inhibitor use in scarring alopecia JAAD reviews. · 2025 · 4 citations
    25. At the crossroads of 2 alopecias: Androgenetic alopecia pattern of hair regrowth in patients with alopecia areata treated with oral Janus kinase inhibitors JAAD case reports · 2020 · 4 citations
    26. Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review Archives of Dermatological Research · 2025 · 3 citations
    27. Evaluating dermatologists’ knowledge of and attitudes toward Janus kinase inhibitor therapy for the treatment of alopecia areata Journal of the American Academy of Dermatology · 2024 · 3 citations
    28. Safety of Janus Kinase inhibitors in Patients with Alopecia Areata: A Systematic Review Clinical drug investigation · 2023 · 3 citations
    29. The relative efficacy of monotherapy with Janus kinase inhibitors, dupilumab and apremilast in adults with alopecia areata: Network meta‐analyses of clinical trials Journal of cosmetic dermatology · 2023 · 2 citations
    30. Janus kinase inhibitors for alopecia areata: A narrative review Indian journal of dermatology, venereology, and leprology · 2023 · 2 citations