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    Glossary Janus Kinase 2

    enzyme involved in cell signaling and blood cell production

    Janus Kinase 2 (JAK2) is an enzyme that plays a crucial role in the signaling pathways of various types of cells, including those involved in the immune system and blood cell production. Mutations in the JAK2 gene are often associated with certain blood disorders and cancers, such as polycythemia vera and essential thrombocythemia, making it a significant target for medical research and treatment development.

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    Research 30 of 1000+

    1. A phase 2a randomized, placebo-controlled study to evaluate the efficacy and safety of the oral Janus kinase inhibitors ritlecitinib and brepocitinib in alopecia areata: 24-week results Journal of the American Academy of Dermatology · 2021 · 138 citations
    2. Tofacitinib 2% ointment, a topical Janus kinase inhibitor, for the treatment of alopecia areata: A pilot study of 10 patients Journal of the American Academy of Dermatology · 2017 · 48 citations
    3. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    4. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    5. Janus kinase inhibition in Down syndrome: 2 cases of therapeutic benefit for alopecia areata JAAD case reports · 2019 · 32 citations
    6. At the crossroads of 2 alopecias: Androgenetic alopecia pattern of hair regrowth in patients with alopecia areata treated with oral Janus kinase inhibitors JAAD case reports · 2020 · 4 citations
    7. SYSTEMATIC REVIEW OF ORAL JANUS KINASE INHIBITORS IN ALOPECIA AREATA: INSIGHTS FROM 2020 TO 2025 STUDIES International Journal of Innovative Technologies in Social Science · 2025
    8. Efficacy and safety of the oral Janus kinase 3/tyrosine kinase expressed in hepatocellular carcinoma family kinase inhibitor ritlecitinib over 24 months: integrated analysis of the ALLEGRO phase IIb/III and long-term phase III clinical studies in alopecia areata British Journal of Dermatology · 2024 · 23 citations
    9. Exploring the efficacy of baricitinib in treating alopecia areata after failed Janus kinase inhibitor therapy JAAD Case Reports · 2023 · 7 citations
    10. 544 Alopecia areata lesions show significant changes in immune and keratin biomarkers that correlate with clinical improvement with oral Janus kinase inhibitors PF-06651600 (JAK3) and PF-06700841 (TYK2/JAK1) Journal of Investigative Dermatology · 2019 · 5 citations
    11. Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review Archives of Dermatological Research · 2025 · 3 citations
    12. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    13. Updates From 2021 Virtual Dermatology Nurses' Association Convention Journal of the Dermatology Nurses' Association · 2021
    14. Ann Robinson’s research reviews —12 May 2022 The BMJ · 2022
    15. Real-world assessment of ritlecitinib in patients with severe alopecia areata: a 24-week multicentre retrospective study Clinical and Experimental Dermatology · 2025 · 3 citations
    16. <i>JAMA Dermatology—</i>The Year in Review, 2021 JAMA Dermatology · 2022
    17. British Association of Dermatologists living guideline for managing people with alopecia areata 2025 British Journal of Dermatology · 2025
    18. Janus kinase inhibitor as a therapeutic option in alopecia areata. Case report Revista colombiana de reumatología · 2023
    19. 22-Year-Old Male with Several Discrete Patches of Hair Loss Clinical Cases in Dermatology · 2022
    20. Inhibidor janus kinasa como opción terapéutica en alopecia areata. Reporte de caso 2021
    21. PSS20 MEDIATION MODELING AND MEASUREMENT CHARACTERISTICS OF THE ITCH SEVERITY SCORE FROM A PHASE 2B TRIAL OF ORAL CP-690-550 IN PATIENTS WITH MODERATE TO-SEVERE PLAQUE PSORIASIS Value in Health · 2011
    22. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase inhibitor, in adults with alopecia areata: Results from the Phase 3 randomized, controlled trial (THRIVE-AA1) Journal of the American Academy of Dermatology · 2024 · 63 citations
    23. Hair regrowth in a patient with central centrifugal cicatricial alopecia after a 2-month trial of baricitinib JAAD Case Reports · 2023 · 2 citations
    24. 33774 Baricitinib results in eyebrow and eyelash growth in patients with alopecia areata who do not achieve 20% or less scalp hair loss Journal of The American Academy of Dermatology · 2022 · 1 citations
    25. S3‐Leitlinie Diagnostik und Therapie der Alopecia areata – Teil 2: Therapie, psychosoziale und kosmetische Unterstützung JDDG Journal der Deutschen Dermatologischen Gesellschaft · 2026
    26. S3 guideline diagnostics and therapy in alopecia areata – Part 2: Therapy, psychosocial and cosmetic support JDDG Journal der Deutschen Dermatologischen Gesellschaft · 2026
    27. 170 Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index Journal of Investigative Dermatology · 2019
    28. Leptin and the skin: a new frontier Experimental Dermatology · 2009 · 108 citations
    29. 0975 Single-cell transcriptomic profiling reveals distinct immunopathogenic programs in alopecia totalis/universalis compared to patchy alopecia areata Journal of Investigative Dermatology · 2026
    30. UHPLC-Q-Orbitrap HRMS-based Metabolomics and In Silico Studies on 5-α-Reductase, JAK1, JAK2, and JAK3 of <i>Albizia saponaria</i> L.: Application to Alopecia Tropical Journal of Natural Product Research · 2026