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    Glossary Janus Kinase Inhibitors

    medications that block enzymes involved in immune response signaling

    Janus Kinase Inhibitors, often referred to as JAK inhibitors, are a class of medications that block the activity of Janus kinases, which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage conditions like rheumatoid arthritis, psoriasis, and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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    Research 30 of 1000+

    1. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    2. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    3. Janus Kinase Inhibitors in Dermatology: Part 1 — General Considerations and Applications in Vitiligo and Alopecia Areata Actas Dermo-Sifiliográficas · 2021 · 14 citations
    4. The Janus kinase 1 inhibitor abrocitinib for the treatment of oral lichen planus 2023 · 7 citations
    5. 170 Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index Journal of Investigative Dermatology · 2019
    6. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    7. Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review Archives of Dermatological Research · 2025 · 3 citations
    8. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    9. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    10. Inhibidores de JAK: usos en dermatología. Parte 1: generalidades, aplicaciones en vitíligo y en alopecia areata Actas Dermo-Sifiliográficas · 2020 · 20 citations
    11. Ruxolitinib 1.5% Topical Cream for the Treatment of Pediatric Alopecia Areata Journal of Drugs in Dermatology · 2024 · 4 citations
    12. Iron Chelators in the Management of Autoimmune-Induced Alopecia: A Focus on Hypoxia-Inducible Factor 1 Modulation and Hair Restoration Journal of Clinical Medicine · 2025
    13. Efficacy of Janus kinase inhibitors in adult patients with alopecia areata International journal of research in dermatology · 2023
    14. The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases 2020 · 70 citations
    15. Selective Janus kinase 1 inhibition resolves inflammation and restores hair growth offering a viable treatment option for alopecia areata Skin health and disease · 2023 · 4 citations
    16. BH21 Efficacy and safety of oral Janus kinase inhibitors in the treatment of alopecia areata: a systematic review and meta-analysis British Journal of Dermatology · 2026
    17. Real-Life Effectiveness and Tolerance of Baricitinib for the Treatment of Severe Alopecia Areata with 1-Year Follow-Up Data Dermatology and Therapy · 2023
    18. 44182 Treatment with Oral Janus Kinase Inhibitors in Adults Patients with Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2023
    19. Safety of Janus Kinase inhibitors in Patients with Alopecia Areata: A Systematic Review Clinical drug investigation · 2023 · 3 citations
    20. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    21. The Use of Janus Kinase Inhibitors for Primary Neutrophilic Cicatricial Alopecias International Journal of Trichology · 2025
    22. Treatment of alopecia areata with the janus kinase inhibitor upadacitinib: A retrospective cohort study Journal of the American Academy of Dermatology · 2023 · 6 citations
    23. Public Interest in Janus Kinase (JAK) IInhibitors for Alopecia Areata: A Google Trend Analysis JMIR Dermatology · 2026
    24. Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials Postgraduate Medical Journal · 2025
    25. Oral and Topical Janus Kinase Inhibitors in Patients With Cutaneous T‐Cell Lymphoma: A Real‐World Single‐Center Experience The Journal of Dermatology · 2025
    26. Treatment of alopecia universalis with topical Janus kinase inhibitors – a double blind, placebo, and active controlled pilot study International Journal of Dermatology · 2018 · 49 citations
    27. Upadacitinib for the treatment of alopecia areata and severe atopic dermatitis in a paediatric patient: A case report SAGE open medical case reports · 2022 · 7 citations
    28. Upadacitinib for management of recalcitrant alopecia areata: A retrospective case series JAAD case reports · 2023 · 3 citations
    29. Upadacitinib for management of alopecia areata and rheumatoid arthritis: Letter to the editor JEADV clinical practice · 2024
    30. Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib ACG Case Reports Journal · 2021 · 2 citations