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    Glossary Janus Kinase Inhibitors

    medications that block enzymes involved in immune response signaling

    Janus Kinase Inhibitors, often referred to as JAK inhibitors, are a class of medications that block the activity of Janus kinases, which are enzymes involved in the signaling pathways that regulate immune responses and inflammation. By inhibiting these enzymes, JAK inhibitors can help manage conditions like rheumatoid arthritis, psoriasis, and certain types of alopecia, where the immune system mistakenly attacks the body's own tissues.

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    Research 30 of 1000+

    1. Efficacy and safety of deuruxolitinib, an oral selective Janus kinase 1/2 inhibitor, in adults with alopecia areata: Results from the THRIVE-AA2 Phase 3, randomized, double-blind, controlled trial Journal of the American Academy of Dermatology · 2025 · 2 citations
    2. Determination of 13 janus kinase inhibitors in anti-alopecia cosmetics by ultra-high performance liquid chromatography-tandem triple quadrupole composite linear ion trap mass spectrometry Chinese Journal of Chromatography · 2025
    3. Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A promising therapy for the treatment of alopecia areata: A case report of six patients International Journal of Trichology · 2018 · 24 citations
    4. 170 Forecasting Phase 3 Dose-Response for Abrocitinib, an Oral Janus Kinase 1 Selective Inhibitor, Using Investigator’s Global Assessment and Eczema Area and Severity Index Journal of Investigative Dermatology · 2019
    5. Frontal fibrosing alopecia shows robust T helper 1 and Janus kinase 3 skewing 2020 · 34 citations
    6. JAK 1-3 inhibitors and TYK-2 inhibitors in dermatology: Practical pearls for the primary care physician Journal of Family Medicine and Primary Care · 2024 · 6 citations
    7. Case Report: Reversal of Long-Standing Refractory Diffuse Non-Scarring Alopecia Due to Systemic Lupus Erythematosus Following Treatment With Tofacitinib Frontiers in Immunology · 2021 · 6 citations
    8. Treatment of Crohn's Disease and Concomitant Alopecia Areata With Tofacitinib ACG Case Reports Journal · 2021 · 2 citations
    9. Tofacitinib for the treatment of severe alopecia areata and variants: A retrospective cohort study of 90 patients Journal of the American Academy of Dermatology · 2017
    10. Autophagy Stimulation Improves Erythroid Proliferative Capacity in Models of SF3B1 Mutant MDS Leukemia research · 2017
    11. Les Rencontres d’Experts du Psoriasis : des recommandations pour la pratique quotidienne Annales de dermatologie et de vénéréologie · 2011
    12. Oral tofacitinib: a promising treatment in atopic dermatitis, alopecia areata and vitiligo Clinical and Experimental Dermatology · 2017 · 37 citations
    13. An urticarial drug eruption caused by tofacitinib for alopecia universalis Dermatologic Therapy · 2019 · 2 citations
    14. Biologics in the management of childhood atopic dermatitis 2023 · 4 citations
    15. Alopecia Areata and Atopic Dermatitis: Common Mechanisms and Emerging Therapeutics Journal of Inflammation Research · 2026
    16. 44182 Treatment with Oral Janus Kinase Inhibitors in Adults Patients with Alopecia Areata: A Systematic Review and Meta-Analysis Journal of the American Academy of Dermatology · 2023
    17. LB785 Efficacy and safety of baricitinib in adults with Alopecia Areata: Phase 3 results from a randomized controlled trial (BRAVE-AA1) Journal of Investigative Dermatology · 2021 · 3 citations
    18. 32237 Clinician and patient evaluation of improvement for eyebrow and eyelashes hair loss during baricitinib phase 3 trials BRAVE-AA1 and BRAVE-AA2 Journal of The American Academy of Dermatology · 2022
    19. The emerging role of Janus kinase inhibitors in the treatment of autoimmune and inflammatory diseases 2020 · 70 citations
    20. The Use of Janus Kinase Inhibitors for Primary Neutrophilic Cicatricial Alopecias International Journal of Trichology · 2025
    21. Safety of Janus Kinase inhibitors in Patients with Alopecia Areata: A Systematic Review Clinical drug investigation · 2023 · 3 citations
    22. Comparative efficacy of Janus kinase inhibitors in severe alopecia areata: a network meta-analysis based on randomized controlled trials Postgraduate Medical Journal · 2025
    23. Efficacy and safety of the oral Janus kinase inhibitor baricitinib in the treatment of adults with alopecia areata: Phase 2 results from a randomized controlled study Journal of The American Academy of Dermatology · 2021 · 66 citations
    24. Oral and Topical Janus Kinase Inhibitors in Patients With Cutaneous T‐Cell Lymphoma: A Real‐World Single‐Center Experience The Journal of Dermatology · 2025
    25. Comparative Efficacy Evaluation of Alopecia Areata Management with Janus Kinase Inhibitors in Children: Retrospective Cohort Study Педиатрическая фармакология · 2025
    26. Public Interest in Janus Kinase (JAK) IInhibitors for Alopecia Areata: A Google Trend Analysis JMIR Dermatology · 2026
    27. Discontinuation and restart of Janus kinase inhibitors due to pregnancy in alopecia areata: a case series International Journal of Women’s Dermatology · 2025
    28. Clinical Outcomes for Uptitration of Baricitinib Therapy in Patients With Severe Alopecia Areata JAMA Dermatology · 2023 · 1 citations
    29. Effectiveness of Baricitinib on Nail Alopecia Areata: A 48-Week Single-Center Retrospective Study Clinical Drug Investigation · 2026
    30. Upadacitinib for management of recalcitrant alopecia areata: A retrospective case series JAAD case reports · 2023 · 3 citations