245 citations
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January 2010 in “Blood” This study suggests that antihepcidin antibodies may effectively treat inflammatory anemia by manipulating iron metabolism, based on experiments conducted in mouse models and hHepc knock-in mice.
4 citations
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March 2019 in “IP Indian Journal of Clinical and Experimental Dermatology” This study observed an association between body iron levels and non-scarring diffuse hair loss in non-menopausal women.
163 citations
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November 2003 in “Journal of Investigative Dermatology” This study found that women with androgenetic alopecia or alopecia areata have significantly lower serum ferritin levels than those without hair loss, suggesting a potential link between these types of alopecia and decreased iron stores.
134 citations
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December 2018 in “Dermatology and Therapy” This review discusses the potential role of vitamins and minerals in managing non-scarring alopecia but reports no clinical results; the authors advocate for further controlled trials to explore these relationships.
63 citations
,
May 2017 in “American Journal of Clinical Dermatology” This review found that patients with alopecia areata may have lower levels of vitamin D, zinc, and folate, but conflicting evidence precludes definitive clinical recommendations for micronutrient supplementation.
38 citations
,
March 2010 in “Medicine” In this study, researchers found that hepatitis C virus infection is a significant risk factor for sporadic porphyria cutanea tarda, suggesting familial cases might be more prevalent in areas with low hepatitis C infection rates.
19 citations
,
January 2015 in “Current problems in dermatology” This review discusses environmental factors like UV radiation and smoking that affect hair health and highlights the potential role of nutrition, but it reports no new results.
10 citations
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September 2023 in “Metabolites” This study reviews iron metabolism in the skin, highlighting how differentially expressed genes regulate iron recycling in the epidermis, and discusses changes in iron metabolism related to skin diseases.
10 citations
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August 2021 in “Journal of Cosmetic Dermatology” This study retrospectively analyzed 3028 patients with telogen effluvium, finding that 6.2% had iron deficiency anemia and vitamin D deficiency was common, especially in women who were more often prescribed vitamin D therapy.
This study found that iron availability influences root hair growth under phosphate starvation by affecting auxin distribution, phosphate starvation-responsive genes, and vesicle trafficking.
2 citations
,
November 2022 in “Bioscience Reports” This review explores the similarities between polycystic ovary syndrome and hemochromatosis in terms of iron overload and suggests that addressing gut dysbiosis might help manage iron levels in these conditions.
July 2026 in “Journal of Cutaneous and Aesthetic Surgery” This review suggests that female and male hair loss patterns differ due to hormonal influences, metabolic factors, and genetic loci, with female pattern hair loss potentially occurring without androgen influence, highlighting the need for distinct clinical management approaches.
This study in mice found that maternal iron deficiency led to hair loss and growth abnormalities in offspring due to increased oxidative stress and disrupted signaling pathways, but postnatal iron supplementation was able to reverse these effects.
This review highlights that iron deficiency is a significant yet often overlooked contributor to the development of immune-mediated inflammatory skin diseases, suggesting that iron dysregulation may drive inflammation and metabolic imbalances in conditions like psoriasis and atopic dermatitis.
September 2025 in “Romanian Journal of Medical Practice” In this study of women with female pattern hair loss, iron deficiency was associated with the condition due to significantly lower serum ferritin and altered hematological indices compared to healthy controls, while no significant differences in serotonin levels or renal function were observed.
January 2025 in “International Journal of Dermatology Venereology and Leprosy Sciences” In this hospital-based study, researchers found that serum ferritin levels were significantly lower in individuals with acne compared to healthy controls, suggesting a possible link between iron deficiency and acne pathogenesis.
August 2023 in “Tzu Chi Medical Journal” This study at a medical center in Eastern Taiwan found that female alopecia has diverse causes, including nutrient deficiencies, autoimmune diseases, psychological stress, thyroid conditions, and COVID-19 vaccination, with iron deficiency affecting 70.3% of cases.
79 citations
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January 2017 in “Dermatology practical & conceptual” This article addresses the need to screen for nutrient deficiencies in patients with hair loss but reports no new findings, noting that supplementation without deficiency may not be beneficial and could pose risks.
56 citations
,
January 2008 in “Dermatology” This article discusses the controversy over serum ferritin levels in diagnosing iron deficiency in women with hair loss but reports no new findings, emphasizing the need for consistent reference ranges.
3 citations
,
December 1956 in “PubMed”
January 2017 in “Egyptian Journal of Dermatology and Venereology” This study found that iron deficiency might play a role in the development of telogen effluvium in premenopausal women, highlighting the importance of checking hemoglobin in acute TE and serum ferritin in chronic TE.
37 citations
,
January 1997 in “Clinics in Dermatology” This study found that women with androgenetic alopecia and alopecia areata had significantly lower serum ferritin levels compared to women without hair loss.
19 citations
,
February 2018 in “Nutrients” This review discusses the relationship between zinc deficiency and skin disorders, emphasizing zinc transporters' roles, but it reports no new clinical results; the authors highlight potential benefits of regulating zinc levels via transporters.
14 citations
,
October 2020 in “Natural Products and Bioprospecting” This review discusses current topical treatments, natural products, and complementary therapies for androgenetic alopecia, but it reports no new clinical results.
November 2025 in “Biological Trace Element Research” This pilot study found no significant relationship between blood and hair mineral concentrations in generally healthy adults, though hair analysis may have potential for assessing long-term mineral trends.
March 2024 in “International journal of molecular sciences” This study suggests that abnormal levels of zinc, copper, and iron in serum or hair may serve as auxiliary and prognostic tests for various skin diseases, though further research is necessary due to conflicting data.
This study developed a mathematical model using hair biomarkers (levels of Mg, K, Fe, Al, Cr) to noninvasively predict iron content in Hereford cattle muscle tissue, potentially improving livestock management and meat quality.
June 2023 in “Journal of Ayurvedic and herbal medicine” This review article highlights the potential health benefits and pharmaceutical components of pumpkin seeds, which contain proteins, antioxidants, and essential nutrients, and discusses their traditional medicinal uses and emerging applications in the food industry.
January 2022 in “Bio web of conferences/BIO web of conferences” This study concluded that the elemental composition of tail brush hair in newborn calves can indicate trace element supply to the fetus during the last months of pregnancy.
24 citations
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May 2019 in “PLOS genetics” This study reports that compound heterozygous loss-of-function mutations in the HEPHL1 gene in a child were associated with abnormal hair and cognitive issues, linking altered ferroxidase activity to hair disorders.