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The Rotterdam Study aims to understand disease causes in the elderly and has found new risk factors and genetic influences on various conditions.

The study found that sweat glands contain different types of stem cells that help with healing and maintaining healthy skin.

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Apoptosis is essential for human skin development and forming a functional epidermis.

Melatonin in the skin helps protect against damage from stress and UV rays, and could be used to treat certain skin conditions.

Human skin can make serotonin and melatonin.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

Dermoscopy is a useful tool for identifying features of skin conditions, but more research is needed to define its role in dermatology.

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

Fat cells help recruit healing cells and build skin structure during wound healing.

Cyproterone acetate is effective for acne but less so for hirsutism and alopecia, with some side effects and quick menstrual cycle recovery after treatment.

Tofacitinib is safe and effective for severe alopecia areata, but hair loss may return 2 months after stopping treatment.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Planarian regeneration begins with a specific gene activation caused by injury, essential for healing and tissue regrowth.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Use minoxidil for hair loss; finasteride and dutasteride for men, dutasteride for women.

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

The document concludes that developing generic topical drugs requires ensuring they match the original in quality, composition, and structure, and often involves complex testing and regulatory steps.

Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.

Hair follicle dermal stem cells are key for regenerating parts of the hair follicle and determining hair type.

Some treatments can help with a hair loss condition called alopecia areata, but none ensure lasting results; choices depend on the person, with JAK inhibitors showing promise for severe cases.

Epigenetic changes control how adult stem cells work and can lead to diseases like cancer if they go wrong.

Oestrogens are key for bone growth during puberty in both boys and girls.

The conclusion is that accurate diagnosis of different types of hair loss requires good teamwork between skin doctors and lab experts.

Hormone treatments for transgender individuals generally improve mental health and physical transition, with some health risks that require medical supervision.

Current treatments for alopecia show no significant long-term benefits.

Stem cell niches support, regulate, and coordinate stem cell functions.

Researchers developed a new model for more realistic computer graphics rendering of hair by considering how light scatters on hair fibers.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.