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Glossary Intermediate Hairs

hairs transitioning between fine vellus and thick terminal types

Intermediate hairs are a type of hair that falls between vellus hairs (fine, short, and lightly pigmented) and terminal hairs (thick, long, and heavily pigmented). These hairs are typically found in areas undergoing a transition, such as during puberty or in certain stages of hair growth cycles, and they exhibit characteristics of both vellus and terminal hairs. For example, they may be longer and more pigmented than vellus hairs but not as coarse or dark as terminal hairs.

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research Trichoscopic characteristics as diagnostic indicators for grading of female pattern hair loss severity in skin of color: A multicentric retrospective study by the International Dermoscopy Society

July 2026 in “Journal of Cutaneous and Aesthetic Surgery”

This study found that trichoscopic quantitative parameters reliably indicate the severity of female pattern hair loss and complement the Sinclair scale by offering a more objective and reproducible grading system.

Autologous Adipose-Derived Stem Cell Versus Platelet-Rich Plasma Injection in the Treatment of Androgenetic Alopecia: Efficacy, Side Effects, and Safety

research Autologous Adipose Derived Stem Cell versus Platelet Rich Plasma Injection in the Treatment of Androgentic Alopecia: Efficacy, Side Effects and Safety

2 citations , January 2018 in “Journal of clinical & experimental dermatology research”

This study suggests that AT-ASCs significantly improve terminal and intermediate hair counts and hair caliber in androgenetic alopecia more than PRP, though with more side effects like headache and erythema.

research Sequence and expression of human hair keratin genes

19 citations , July 1994 in “Journal of Dermatological Science”

This study identified and characterized human hair-specific keratin genes, revealing their sequence homology with mouse counterparts and expression in hair follicle precortical cells.

research Imaging Tools for Noninvasive Hair Assessment

July 2023 in “Cutis”

This review discusses recent advances in noninvasive hair imaging technologies, such as global photography, trichoscopy, reflectance confocal microscopy, and optical coherence tomography, highlighting their potential to improve hair diagnostics and treatment monitoring, while also outlining their clinical applications and limitations.

research Management of androgenetic alopecia

40 citations , May 1999 in “Journal of The European Academy of Dermatology and Venereology”

This article outlines management guidelines for androgenetic alopecia, highlighting that continued treatment with medications like finasteride or minoxidil typically halts progression and improves hair condition in most mild to moderate cases.

Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice

research Prolactin Signaling Influences the Timing Mechanism of the Hair Follicle: Analysis of Hair Growth Cycles in Prolactin Receptor Knockout Mice*

73 citations , June 2001 in “Endocrinology”

In this study, researchers found that disrupting the PRL gene in mice led to earlier hair molting, especially in females, suggesting that PRL inhibits murine hair cycle events.

research Intermediate hair follicles: a new more clinically relevant model for hair growth investigations

30 citations , May 2010 in “British Journal of Dermatology”

This study found that intermediate hair follicles are morphologically distinct from terminal follicles and offer a novel model for developing new alopecia therapies despite being technically more challenging to study.

research Structure of intermediate filament assembly in hair deduced from hydration studies using small-angle neutron scattering

9 citations , April 2019 in “Journal of structural biology”

This study found that coconut oil impedes hair hydration more effectively than soybean oil by penetrating deeper, and suggested a new model for intermediate filament assembly in hair.

research Hair counts in scalp biopsy of males and females with androgenetic alopecia compared with normal subjects

40 citations , June 2009 in “Journal of Cutaneous Pathology”

This study found that Iranian patients with androgenetic alopecia had a higher terminal to vellus hair ratio compared to previous studies in Whites, suggesting potential onset of miniaturization.

research Changes in hair weight and hair count in men with androgenetic alopecia after treatment with finasteride, 1 mg, daily

66 citations , April 2002 in “Journal of The American Academy of Dermatology”

In this study, finasteride, 1 mg daily, significantly increased hair weight more than hair count in men with androgenetic alopecia, indicating additional factors like hair growth rate and thickness may contribute to its effectiveness.

Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

22 citations , June 2012 in “PLOS ONE”

In this study, researchers found that impaired cholesterol biosynthesis in hair follicles may trigger an inflammatory immune response linked to primary cicatricial alopecia, providing new insights into the disorder's pathogenesis.

Single-Cell Sequencing Reveals the Intermediate Cell State and Function of Dermal Papilla Cells in the Hair Follicle Cycle of Cashmere Goats

research Single-cell sequencing reveals the intermediate cell state and function of dermal papilla cells in the hair follicle cycle of cashmere goats

May 2020 in “Research Square (Research Square)”

This study used cashmere goats to reveal distinct intermediate states of dermal papilla cells, each with specific roles in hair growth, shedding, and regeneration.

research Oxidative stress management in the hair follicle: Could targeting NRF2 counter age‐related hair disorders and beyond?

30 citations , July 2017 in “BioEssays”

This review discusses the potential benefits of activating NRF2 for treating hair follicle disorders linked to oxidative stress and reports no new clinical results.

research Hair follicle gene expression profiling in the SubPopulations and InteRmediate Outcome Measures in COPD Study (SPIROMICS)

December 2025 in “BMC Medical Genomics”

This study demonstrated that RNA-seq can effectively expand hair follicle transcriptomic profiling in a multi-center study, offering deeper insights than blood transcriptomics alone.

research Effect of Aspartic Acid Intermediate Treatment on Virgin Hair by Permanent Wave

1 citations , April 2021 in “Han'gug miyong haghoeji/Journal of the Korean society of cosmetology”

In this study, researchers found that using 0.75% aspartic acid as an intermediate agent for a permanent wave improved wave formation and retention compared to a control in virgin hair, also reducing cuticle damage and maintaining tensile strength.

research Heterotypic cell contacts and basal lamina morphology during hair follicle development in the mouse: a light, scanning, and electron microscopic study at the site of tissue interaction

13 citations , December 1983 in “Canadian journal of zoology”

This study found that mesenchymal cell processes from the dermal papilla contact epithelial hair matrix cells through gaps in the basal lamina during hair matrix cell differentiation in mouse vibrissa follicles.

research Intermediate Hair Follicles from Patients with Female Pattern Hair Loss Are Associated with Nutrient Insufficiency and a Quiescent Metabolic Phenotype

August 2022 in “Nutrients”

This ex vivo study found that hair follicles in female pattern hair loss exhibited nutrient insufficiency and dormant metabolism, but maintained nutrient uptake capability, suggesting potential benefits of nutritional supplementation as an adjunct therapy.

A 6-Month Prospective, Open-Label, Randomized Study Showing Increased Hair Growth Rate in Women Using Multi-Targeting Hair Growth Nutraceuticals

research A 6-Month Prospective, Open-Label, Randomized Study Showing Increased Hair Growth Rate in Women Using Multi-Targeting Hair Growth Nutraceuticals

July 2026 in “Dermatology and Therapy”

In this study, women experiencing hair thinning who consumed tailored botanical-based nutraceuticals saw significant increases in linear hair growth rate and other hair health parameters over 90 and 180 days, supporting their effectiveness across different life stages.

research Understanding the biochemical properties of human hair keratins : self-assembly potential and cell response

January 2020

This Ph.D. project aims to evaluate the self-assembling potential of hair keratin extracts and study the cellular response to both crude and purified keratins, highlighting their potential applications from biomedical to water remediation.

research Local structure of human hair spatially resolved by sub-micron X-ray beam

24 citations , November 2015 in “Scientific reports”

This study discovered a new region in the hair cortex where intermediate filaments are both aligned with the hair's axis and orientationally ordered, influenced by the cuticle boundary.

research Sequence analyses of Type I and Type II chains in human hair and epithelial keratin intermediate filaments: Promiscuous obligate heterodimers, Type II template for molecule formation and a rationale for heterodimer formation

19 citations , December 2006 in “Journal of Structural Biology”

Type I and Type II keratin chains can form heterodimers despite sequence differences.

research Single-Cell Transcriptomic Identification of a Proliferative Intermediate State During Early Anagen Hair Follicle Regeneration

August 2026 in “Genes”

This study identified a proliferative intermediate transcriptional state associated with the transition from secondary hair germ cells to lower hair follicle-associated cells during early hair follicle regeneration in mice.

research Patch tests with commercial hair dye products in patients with allergic contact dermatitis to para-phenylenediamine

6 citations , January 2016 in “Indian Journal of Dermatology Venereology and Leprology”

This study found that the majority of "hypoallergenic" hair dyes still triggered allergic reactions in patients sensitive to para-phenylenediamine.

research HIGH DEVELOPMENTAL AGE AND POOR HAIR MULTI-ELEMENT PROFILE IN A 3.75-YEAR-OLD GIRL − DIFFERENTIAL RATES IN SHAPING OF BODY ORGAN GROWTH

1 citations , January 2015 in “Trace Elements in Medicine (Moscow)”

This case study reports that different organs, such as hair and stature, may grow at varying rates during different stages of growth.

research Evaluation of hair loss

21 citations , May 1996 in “Current problems in dermatology”

This article reviews various causes and investigative techniques for different forms of alopecia and reports no new findings.

Androgens Trigger Different Growth Responses in Genetically Identical Human Hair Follicles in Organ Culture Reflecting Their Epigenetic Diversity in Life

research Androgens trigger different growth responses in genetically identical human hair follicles in organ culture that reflect their epigenetic diversity in life

19 citations , October 2017 in “The FASEB Journal”

This study established an androgen-responsive human organ culture model using hair follicles, demonstrating that women's intermediate facial follicles grow more hair in response to men's higher androgen levels.